NITROMIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H5N3O5
Molecular Weight	211.1317
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1=CC(=CC(=C1)[N+]([O-])=O)[N+]([O-])=O

InChI

InChIKey=UUKWKUSGGZNXGA-UHFFFAOYSA-N

InChI=1S/C7H5N3O5/c8-7(11)4-1-5(9(12)13)3-6(2-4)10(14)15/h1-3H,(H2,8,11)

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/nitromide.html | https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol6/pdf/CFR-1996-title21-vol6-sec558-376.pdf

Nitromide is an anti-parasitic agent. In combination with sulfanitran (Unistat) it was used as an aid in the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, and E. acervulina.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Eimeria tenella 10 Target ID: CHEMBL612854 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4744839	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: https://www.drugs.com/international/nitromide.html https://www.gpo.gov/fdsys/pkg/CFR-1996-title21-vol6/pdf/CFR-1996-title21-vol6-sec558-376.pdf	Curative		Approved 8429	UNISTAT-2 Approved Use Indications for use. As an aid in the prevention of coccidiosis caused by Eimeria tenella, E. necatrix, and E. acervulina.

PubMed

Title	Date	PubMed
Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.	1996 Dec	9039272
Solid-phase synthesis of chiral stationary phases based on 2,4,5,6-tetrachloro-1,3-dicyanobenzene derivatives spaced from N-3,5-dinitrobenzoyl alpha-amino acids: comparative study of their resolution efficacy.	2001 Jun	11370018
Elucidation of the chiral recognition mechanism of cinchona alkaloid carbamate-type receptors for 3,5-dinitrobenzoyl amino acids.	2002 Jul 24	12121103
PnrA, a new nitroreductase-family enzyme in the TNT-degrading strain Pseudomonas putida JLR11.	2005 Aug	16011758
Determination of enantiomeric composition by negative-ion electrospray ionization-mass spectrometry using deprotonated N-(3,5-dinitrobenzoyl)amino acids as chiral selectors.	2005 Oct	16100716
Pi-Pi complexation of bupivacaine and analogues with aromatic receptors: implications for overdose remediation.	2007	18019843
A comprehensive chemoselective and enantioselective 2D-HPLC set-up for fast enantiomer analysis of a multicomponent mixture of derivatized amino acids.	2007 Aug	17619865
Discrimination of enantiomers of alpha-amino acids by chiral derivatizing reagents from trans-1,2-diaminocyclohexane.	2008 Mar	17600850
Continuous separation of racemic 3,5-dinitrobenzoyl-amino acids in a centrifugal contact separator with the aid of cinchona-based chiral host compounds.	2009	19142941
Charge-transfer interaction between poly(9-vinylcarbazole) and 3,5-dinitrobenzamido group or 3-nitrobenzamido group.	2010 Mar 2	19919049

Patents

Sample Use Guides

In Vivo Use Guide

Chickens: 227 grams per ton nitromide (0.025 percent) and 272 grams per ton sulfanitran (0.03 percent).

Route of Administration: Oral

In Vitro Use Guide

Nitromide was active against Eimeria tenella at 100 ug/ml.

Name

Type

Language

NITROMIDE

Official Name

English

BENZAMIDE, 3,5-DINITRO-

Systematic Name

English

NITROMIDE [USAN]

Common Name

English

UNISTAT 2 COMPONENT NITROMIDE

Common Name

English

3,5-Dinitrobenzamide

Systematic Name

English

NITROMIDE [GREEN BOOK]

Common Name

English

NSC-60719

Code

English

NITROMIDE [MI]

Common Name

English

Code System Code Type Description

CAS

121-81-3