TRAMAZOLINE HYDROCHLORIDE MONOHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H17N3.ClH.H2O
Molecular Weight	269.77
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TRAMAZOLINE HYDROCHLORIDE MONOHYDRATE

Structure Search

SMILES

O.Cl.C1CN=C(NC2=CC=CC3=C2CCCC3)N1

InChI

InChIKey=FDPYEAXJRLQOGE-UHFFFAOYSA-N

InChI=1S/C13H17N3.ClH.H2O/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13;;/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16);1H;1H2

HIDE SMILES / InChI

Description
Sources: http://www.mydr.com.au/medicines/cmis/spray-tish-nasal-spray | https://www.ncbi.nlm.nih.gov/pubmed/23300 | https://www.ncbi.nlm.nih.gov/pubmed/627

Tramazoline is a sympathomimetic drug that is used in the form of tramazoline hydrochloride in nasal decongestant preparations. Tramazoline is an α-adrenergic receptor agonist that inhibits secretion of nasal mucus.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-2 114 Target ID: CHEMBL2093864 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6142954 \| https://www.ncbi.nlm.nih.gov/pubmed/6093449	Agonist 2752		16.0 nM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rhinitis 19 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26539289	Primary		Approved 8583	Spray-Tish Approved Use Spray-Tish is a nasal decongestant. It works by clearing a stuffy or blocked nose by shrinking the inflamed and swollen blood vessels in the lining of the nose. Spray-Tish relieves a stuffy or blocked nose (nasal congestion) associated with the common cold, hayfever and rhinitis. A runny nose, nasal congestion, itching and sneezing, are typical symptoms of a condition known as rhinitis.

Doses

Dose	Population	Adverse events
0.09 mg 4 times / day multiple, intranasal Recommended Dose: 0.09 mg, 4 times / day Route: intranasal Route: multiple Dose: 0.09 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/26539289/	unhealthy, CHILD\|ADOLESCENT\|ADULT Health Status: unhealthy Age Group: CHILD\|ADOLESCENT\|ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/26539289/	Sources: https://pubmed.ncbi.nlm.nih.gov/26539289/

PubMed

Title	Date	PubMed
The effect of nasal steroid administration on intraocular pressure.	2007-07	17702318
Tramazoline turns asymptomatic into symptomatic hyper-CK-emia.	2007-03	17355540
The prevalence of allergic asthma and rhinitis in children of Polichni, Thessaloniki.	2004-04-17	15087091
[The tolerability of nasal drugs with special regard to preservatives and physico-chemical parameters].	2003-11	14634896
Effects of topical mydriatics and vasoconstrictors on prostaglandin-E2-induced aqueous flare elevation in pigmented rabbits.	2002-12-24	12920338

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose for adults and children six years of age and over is 1 to 2 sprays into each nostril up to four times daily as required.

Route of Administration: Nasal

In Vitro Use Guide

Binding affinity of Tramazoline against Alpha-2 adrenergic receptor measured as the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain membranes by 50% was 16 nM.

Name

Type

Language

1H-IMIDAZOL-2-AMINE, 4,5-DIHYDRO-N-(5,6,7,8-TETRAHYDRO-1-NAPHTHALENYL)-, MONOHYDROCHLORIDE, MONOHYDRATE

Preferred Name

English

TRAMAZOLINE HYDROCHLORIDE MONOHYDRATE

Common Name

English

TRAMAZOLINE HYDROCHLORIDE MONOHYDRATE [EP MONOGRAPH]

Common Name

English

N-(5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL)-4,5-DIHYDRO-1H-IMIDAZOL-2-AMINE HYDROCHLORIDE MONOHYDRATE

Systematic Name

English

Code System Code Type Description

CAS

74195-73-6