Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H17NO2 |
| Molecular Weight | 279.3331 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC3=CC=CC=C3C4=C5OCOC5=CC(CCN1C)=C24
InChI
InChIKey=JCTYWRARKVGOBK-AWEZNQCLSA-N
InChI=1S/C18H17NO2/c1-19-7-6-12-9-15-18(21-10-20-15)17-13-5-3-2-4-11(13)8-14(19)16(12)17/h2-5,9,14H,6-8,10H2,1H3/t14-/m0/s1
Aporeine (Roemerine) is an aporphine alkaloid that can be isolated from many plants such as Annona
senegalensis, Turkish Papaver and Rollinialeptopetala. Aporeine has been reported to exhibit antibacterial activity. It has also been demonstrated to have certain antifungal activity. Aporeine showed selective inhibitory effect on Cox-2.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL230 |
|||
Target ID: CHEMBL352 |
|||
Target ID: CHEMBL366 |
|||
Target ID: CHEMBL364 |
17.9 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
Sample Use Guides
After bacterial challenge for 1 h, mice were randomized to receive i.p. injection of Aporeine (Roemerine) at 20 mg/kg once daily for 2 d. The survival rates for roemerine 20 mg/kg was 58.3%, the survival rate of the model group was only 8.3%.
Route of Administration:
Intraperitoneal
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
800239
Created by
admin on Sat Dec 16 09:33:29 GMT 2023 , Edited by admin on Sat Dec 16 09:33:29 GMT 2023
|
PRIMARY | |||
|
9C0X3XW6QA
Created by
admin on Sat Dec 16 09:33:29 GMT 2023 , Edited by admin on Sat Dec 16 09:33:29 GMT 2023
|
PRIMARY | |||
|
m2005
Created by
admin on Sat Dec 16 09:33:29 GMT 2023 , Edited by admin on Sat Dec 16 09:33:29 GMT 2023
|
PRIMARY | Merck Index | ||
|
2030-53-7
Created by
admin on Sat Dec 16 09:33:29 GMT 2023 , Edited by admin on Sat Dec 16 09:33:29 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD
