Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H17NO2 |
| Molecular Weight | 279.3331 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC3=CC=CC=C3C4=C5OCOC5=CC(CCN1C)=C24
InChI
InChIKey=JCTYWRARKVGOBK-AWEZNQCLSA-N
InChI=1S/C18H17NO2/c1-19-7-6-12-9-15-18(21-10-20-15)17-13-5-3-2-4-11(13)8-14(19)16(12)17/h2-5,9,14H,6-8,10H2,1H3/t14-/m0/s1
| Molecular Formula | C18H17NO2 |
| Molecular Weight | 279.3331 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Aporeine (Roemerine) is an aporphine alkaloid that can be isolated from many plants such as Annona
senegalensis, Turkish Papaver and Rollinialeptopetala. Aporeine has been reported to exhibit antibacterial activity. It has also been demonstrated to have certain antifungal activity. Aporeine showed selective inhibitory effect on Cox-2.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL230 |
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Target ID: CHEMBL352 |
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Target ID: CHEMBL366 |
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Target ID: CHEMBL364 |
17.9 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
Sample Use Guides
After bacterial challenge for 1 h, mice were randomized to receive i.p. injection of Aporeine (Roemerine) at 20 mg/kg once daily for 2 d. The survival rates for roemerine 20 mg/kg was 58.3%, the survival rate of the model group was only 8.3%.
Route of Administration:
Intraperitoneal
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:33:29 GMT 2023
by
admin
on
Sat Dec 16 09:33:29 GMT 2023
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| Record UNII |
9C0X3XW6QA
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| Record Status |
Validated (UNII)
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800239
Created by
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9C0X3XW6QA
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m2005
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admin on Sat Dec 16 09:33:29 GMT 2023 , Edited by admin on Sat Dec 16 09:33:29 GMT 2023
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2030-53-7
Created by
admin on Sat Dec 16 09:33:29 GMT 2023 , Edited by admin on Sat Dec 16 09:33:29 GMT 2023
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