MORPHICEPTIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H35N5O5
Molecular Weight	521.608
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H](CC1=CC=C(O)C=C1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N4CCC[C@H]4C(N)=O

InChI

InChIKey=LSQXZIUREIDSHZ-ZJZGAYNASA-N

InChI=1S/C28H35N5O5/c29-21(16-19-10-12-20(34)13-11-19)27(37)33-15-5-9-24(33)26(36)31-22(17-18-6-2-1-3-7-18)28(38)32-14-4-8-23(32)25(30)35/h1-3,6-7,10-13,21-24,34H,4-5,8-9,14-17,29H2,(H2,30,35)(H,31,36)/t21-,22-,23-,24-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8819146 | https://www.ncbi.nlm.nih.gov/pubmed/26944625

Morphiceptin (Tyr-Pro-Phe-Pro-NH2), an amide of a fragment of the milk protein beta-casein, is a selective ligand of the mu opioid receptor, an important target in pain regulation. Now is used the analogs of morphiceptin, which are studied for the treatment of different diseases.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Mu-type opioid receptor 61 Target ID: P35372\|\|\|G8XRH8\|\|\|Q5TDA1\|\|\|Q9UN57 Gene ID: 4988.0 Gene Symbol: OPRM1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/6259732	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Differential cardiovascular effects of mu, delta and kappa opiate agonists at discrete hypothalamic sites in the anesthetized rat.	1982 Nov 15-22	6131355
Morphine and morphiceptin increase the threshold for epinephrine-induced cardiac arrhythmias in the rat through brain mu opioid receptors.	1993 Feb	8383026

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

MORPHICEPTIN

Common Name

English

DEPROCEPTIN

Common Name

English

L-PROLINAMIDE, L-TYROSYL-L-PROLYL-L-PHENYLALANYL-

Systematic Name

English

Code System Code Type Description

FDA UNII

97TZA8ANPC