MORPHICEPTIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H35N5O5
Molecular Weight	521.608
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H](CC1=CC=C(O)C=C1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N4CCC[C@H]4C(N)=O

InChI

InChIKey=LSQXZIUREIDSHZ-ZJZGAYNASA-N

InChI=1S/C28H35N5O5/c29-21(16-19-10-12-20(34)13-11-19)27(37)33-15-5-9-24(33)26(36)31-22(17-18-6-2-1-3-7-18)28(38)32-14-4-8-23(32)25(30)35/h1-3,6-7,10-13,21-24,34H,4-5,8-9,14-17,29H2,(H2,30,35)(H,31,36)/t21-,22-,23-,24-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8819146 | https://www.ncbi.nlm.nih.gov/pubmed/26944625

Morphiceptin (Tyr-Pro-Phe-Pro-NH2), an amide of a fragment of the milk protein beta-casein, is a selective ligand of the mu opioid receptor, an important target in pain regulation. Now is used the analogs of morphiceptin, which are studied for the treatment of different diseases.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Mu-type opioid receptor 61 Target ID: P35372\|\|\|G8XRH8\|\|\|Q5TDA1\|\|\|Q9UN57 Gene ID: 4988.0 Gene Symbol: OPRM1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/6259732	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases.	2014-10	25149976
Morphine and morphiceptin increase the threshold for epinephrine-induced cardiac arrhythmias in the rat through brain mu opioid receptors.	1993-02	8383026
Modified oligopeptides designed to interact with the HIV-1 proteinase inhibit viral replication.	1990	2241573
Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.	1989-04	2540324
Involvement of the mu-opiate receptor in peripheral analgesia.	1989	2557556
Opiate-induced seizures: a study of mu and delta specific mechanisms.	1986-08	3015659
Differential cardiovascular effects of mu, delta and kappa opiate agonists at discrete hypothalamic sites in the anesthetized rat.	1982-11-15	6131355

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

DEPROCEPTIN

Preferred Name

English

MORPHICEPTIN

Common Name

English

L-PROLINAMIDE, L-TYROSYL-L-PROLYL-L-PHENYLALANYL-

Systematic Name

English

Code System Code Type Description

FDA UNII

97TZA8ANPC