SB-706375

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H22BrF3N2O5S
Molecular Weight	539.363
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=CC(Br)=C(C=C1OC)S(=O)(=O)NC2=CC(O[C@@H]3CCN(C)C3)=C(C=C2)C(F)(F)F

InChI

InChIKey=BPOWQJYAMDEAFF-CYBMUJFWSA-N

InChI=1S/C20H22BrF3N2O5S/c1-26-7-6-13(11-26)31-16-8-12(4-5-14(16)20(22,23)24)25-32(27,28)19-10-18(30-3)17(29-2)9-15(19)21/h4-5,8-10,13,25H,6-7,11H2,1-3H3/t13-/m1/s1

HIDE SMILES / InChI

Description

SB-706375 is a potent, surmountable, reversible and selective mammalian urotensin-II receptor antagonist. In rats SB-706375 provoked a pronounced diuresis and natriuresis, accompanied by modest increases in effective renal blood flow and glomerular filtration rate.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Urotensin II receptor	Antagonist		9.3 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown

PubMed

Title	Date	PubMed
No data available in table

Patents

Sample Use Guides

In Vivo Use Guide

rats: 0.01 mg/kg/min

Route of Administration: Intravenous

In Vitro Use Guide

SB-706375 (0.3–3.0 mM) is a competitive antagonist of urotensin-II-induced contraction of the rat isolated aorta

Show entries

Name

Type

Language

SB-706375

Code

English

2-BROMO-4,5-DIMETHOXYN-(3-(((3R)-1-METHYL-3-PYRROLIDINYL)OXY)-4-(TRIFLUOROMETHYL)PHENYL)BENZENESULFONAMIDE

Systematic Name

English

SB706375

Code

English

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Show entries

Code System

Code

Type

Description

FDA UNII

96711H97SD

PRIMARY

PUBCHEM

21023902

PRIMARY

CAS

733734-61-7

PRIMARY

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ACTIVE MOIETY


					96711H97SD

SB-706375