Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H9N3O2.H2O |
| Molecular Weight | 149.1484 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.CN(CC(O)=O)C(N)=N
InChI
InChIKey=MEJYXFHCRXAUIL-UHFFFAOYSA-N
InChI=1S/C4H9N3O2.H2O/c1-7(4(5)6)2-3(8)9;/h2H2,1H3,(H3,5,6)(H,8,9);1H2
Creatine is an amino acid that occurs in vertebrate tissues and in urine. It is synthesized mainly in the liver from three different amino acids: arginine, glycine, and methionine. In skeletal muscles, which store 95% of it, creatine generally occurs as phosphocreatine. The rest is stored in the brain, heart, and testes. Creatine functions as part of the cell's energy shuttle. It is excreted as creatinine in the urine.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Interstitial nephritis in a patient taking creatine. | 1999 Mar 11 |
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| Evolution and physiological roles of phosphagen systems. | 2001 |
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| Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. | 2001 Apr |
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| A controlled trial of topical nitroglycerin in a New Zealand white rabbit model of brown recluse spider envenomation. | 2001 Feb |
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| Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats. | 2001 Feb |
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| Emergency department evaluation of chest pain using exercise stress echocardiography. | 2001 Feb |
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| Sensitivity of quantitative (1)H magnetic resonance spectroscopy of the brain in detecting early neuronal damage in systemic lupus erythematosus. | 2001 Feb |
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| Mouse model of myocardial remodelling after ischemia: role of intercellular adhesion molecule-1. | 2001 Feb 1 |
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| Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation. | 2001 Feb 2 |
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| Creatine supplementation affects muscle creatine during energy restriction. | 2001 Jan |
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| Treatment of exercise-induced muscle injury via hyperbaric oxygen therapy. | 2001 Jan |
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| Oxygen free radical generation in healthy blood donors and cardiac patients: the protective effect of allopurinol. | 2001 Jan |
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| Alterations in myocardial creatinine kinase (CK) and lactate dehydrogenase (LDH) isoenzyme-distribution in a model of left ventricular dysfunction. | 2001 Jan |
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| Pretreatment of human myocardium with adenosine. | 2001 Jan |
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| Apparent diffusion coefficients in the evaluation of high-grade cerebral gliomas. | 2001 Jan |
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| Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities. | 2001 Jan |
|
| Win, place, show: creatine consumption and the price of winning. | 2001 Jan |
|
| Magnetic resonance imaging and spectroscopic changes in brains of patients with cerebrotendinous xanthomatosis. | 2001 Jan |
|
| Supplemental creatine may decrease serum homocysteine and abolish the homocysteine 'gender gap' by suppressing endogenous creatine synthesis. | 2001 Jan |
|
| A genome scan for renal function among hypertensives: the HyperGEN study. | 2001 Jan |
|
| Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease. | 2001 Jan |
|
| Altered mitochondrial sensitivity for ADP and maintenance of creatine-stimulated respiration in oxidative striated muscles from VDAC1-deficient mice. | 2001 Jan 19 |
|
| Assessment of coronary reperfusion in patients with myocardial infarction using fatty acid binding protein concentrations in plasma. | 2001 Mar |
Patents
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FDA ORPHAN DRUG |
298309
Created by
admin on Fri Dec 15 18:36:38 GMT 2023 , Edited by admin on Fri Dec 15 18:36:38 GMT 2023
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| Code System | Code | Type | Description | ||
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Creatine monohydrate
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931
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C1505
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CONCEPT | Dietary Supplement | ||
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1310467
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PRIMARY | RxNorm | ||
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9603LN7R2Q
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9603LN7R2Q
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80116
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DTXSID10208954
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SUB22738
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C28945
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6020-87-7
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100000086558
Created by
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ACTIVE MOIETY
SUBSTANCE RECORD
