DIMETHYLTUBOCURARINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C39H45N2O6
Molecular Weight	637.7844
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 3
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C2C[C@@H]3C4=C(CC[N+]3(C)C)C=C(OC)C(OC)=C4OC5=CC=C(C[C@@H]6N(C)CCC7=CC(OC)=C(OC1=C2)C=C67)C=C5

InChI

InChIKey=GMAJRXOYQVZSRJ-IOWSJCHKSA-N

InChI=1S/C39H45N2O6/c1-40-16-14-26-21-33(43-5)35-23-29(26)30(40)18-24-8-11-28(12-9-24)46-39-37-27(22-36(44-6)38(39)45-7)15-17-41(2,3)31(37)19-25-10-13-32(42-4)34(20-25)47-35/h8-13,20-23,30-31H,14-19H2,1-7H3/q+1/t30-,31+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9915319 | https://www.ncbi.nlm.nih.gov/pubmed/12799358 | https://jamanetwork.com/journals/jama/article-abstract/290538

Dimethyltubocurarine (metocurine) is a non-depolarizing muscle relaxant. It binds to muscle acetylcholine receptor by bridging the to alpha and non-alpha subunits from the ligand binding site. Dimethyltubocurarine was used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.

Approval Year

Sample Use Guides

In Vivo Use Guide

Dimethyl-tubocurarine iodide is administered intravenously in isotonic sodium chloride solution for muscle relaxtion in surgery. The average initial dose is approximately 2 mg (80 units) and is injected slowly over a period of one to one and one-half minutes.

Route of Administration: Intravenous

Name

Type

Language

DIMETHYLTUBOCURARINE

Common Name

English

DIMETHYL-D-TUBOCURARINE

Preferred Name

English

13H-4,6:21,24-DIETHENO-8,12-METHENO-1H-PYRIDO(3',2':14,15)(1,11)DIOXACYCLOEICOSINO(2,3,4-IJ)ISOQUINOLINIUM, 2,3,13A,14,15,16,25,25A-OCTAHYDRO-9,18,19,29-TETRAMETHOXY-1,14,14-TRIMETHYL-, (13AR,25AS)-

Systematic Name

English

DIMETHYLTUBOCURARINE [BAN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

M03AA04