U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C39H45N2O6.I
Molecular Weight 764.6889
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMETHYLTUBOCURARINE IODIDE

SMILES

[I-].COC1=CC=C2C[C@@H]3C4=C(CC[N+]3(C)C)C=C(OC)C(OC)=C4OC5=CC=C(C[C@@H]6N(C)CCC7=CC(OC)=C(OC1=C2)C=C67)C=C5

InChI

InChIKey=ZRILZUBJODJELN-LBYXUWKHSA-M
InChI=1S/C39H45N2O6.HI/c1-40-16-14-26-21-33(43-5)35-23-29(26)30(40)18-24-8-11-28(12-9-24)46-39-37-27(22-36(44-6)38(39)45-7)15-17-41(2,3)31(37)19-25-10-13-32(42-4)34(20-25)47-35;/h8-13,20-23,30-31H,14-19H2,1-7H3;1H/q+1;/p-1/t30-,31+;/m0./s1

HIDE SMILES / InChI

Molecular Formula HI
Molecular Weight 127.91241
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C39H45N2O6
Molecular Weight 637.7844
Charge 1
Count
Stereochemistry EPIMERIC
Additional Stereochemistry No
Defined Stereocenters 2 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Dimethyltubocurarine (metocurine) is a non-depolarizing muscle relaxant. It binds to muscle acetylcholine receptor by bridging the to alpha and non-alpha subunits from the ligand binding site. Dimethyltubocurarine was used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.

Approval Year

Sample Use Guides

In Vivo Use Guide
Dimethyl-tubocurarine iodide is administered intravenously in isotonic sodium chloride solution for muscle relaxtion in surgery. The average initial dose is approximately 2 mg (80 units) and is injected slowly over a period of one to one and one-half minutes.
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:03:48 GMT 2025
Edited
by admin
on Mon Mar 31 22:03:48 GMT 2025
Record UNII
0Q5R726FHX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIMETHYLTUBOCURARINE IODIDE
Common Name English
TUBOCURARANIUM, 6,6',7',12'-TETRAMETHOXY-2,2',2'-TRIMETHYL-, IODIDE
Preferred Name English
Code System Code Type Description
FDA UNII
0Q5R726FHX
Created by admin on Mon Mar 31 22:03:48 GMT 2025 , Edited by admin on Mon Mar 31 22:03:48 GMT 2025
PRIMARY
CAS
36653-49-3
Created by admin on Mon Mar 31 22:03:48 GMT 2025 , Edited by admin on Mon Mar 31 22:03:48 GMT 2025
PRIMARY
PUBCHEM
76957755
Created by admin on Mon Mar 31 22:03:48 GMT 2025 , Edited by admin on Mon Mar 31 22:03:48 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY