Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C7H10N2O4 |
Molecular Weight | 186.1653 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(C[C@H](N)C(O)=O)C(=O)NO1
InChI
InChIKey=UUDAMDVQRQNNHZ-YFKPBYRVSA-N
InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/6133955
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6133955
AMPA, L- or S-AMPA, an active isomer of (RS)-AMPA, is a selective agonist of AMPA subtype of glutamate receptors.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2096670 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9651156 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6133955
L-AMPA was more effective (IC50 = 0.6 microM) than D-AMPA (IC50 = 4.8 microM) in displacing racemic [3H]AMPA from binding sites on rat brain synaptic membranes in agreement with their relative in vivo excitatory potencies.
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m1845
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158397
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SUBSTANCE RECORD