AMPA, L-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C7H10N2O4
Molecular Weight	186.1653
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C[C@H](N)C(O)=O)C(=O)NO1

InChI

InChIKey=UUDAMDVQRQNNHZ-YFKPBYRVSA-N

InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C7H10N2O4
Molecular Weight	186.1653
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6133955

AMPA, L- or S-AMPA, an active isomer of (RS)-AMPA, is a selective agonist of AMPA subtype of glutamate receptors.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate receptor ionotropic AMPA 41 Target ID: CHEMBL2096670 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9651156	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

L-AMPA was more effective (IC50 = 0.6 microM) than D-AMPA (IC50 = 4.8 microM) in displacing racemic [3H]AMPA from binding sites on rat brain synaptic membranes in agreement with their relative in vivo excitatory potencies.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:49:28 GMT 2023` Edited by `admin` on `Sat Dec 16 09:49:28 GMT 2023`
Record UNII	9280SC28GD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMPA, L-

Common Name

English

S-AMPA

Common Name

English

L-AMPA [MI]

Common Name

English

4-ISOXAZOLEPROPANOIC ACID, .ALPHA.-AMINO-2,3-DIHYDRO-5-METHYL-3-OXO-, (.ALPHA.S)-

Common Name

English

Code System Code Type Description

CAS

83643-88-3