Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H24O2 |
| Molecular Weight | 236.3499 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@H](C)[C@@]13C[C@@H](C(C)C)[C@@](O)(CC2=C)O3
InChI
InChIKey=QRMPRVXWPCLVNI-YYFQZIEXSA-N
InChI=1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h9,11-13,16H,3,5-8H2,1-2,4H3/t11-,12-,13-,14-,15+/m0/s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/27125675
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/27125675
Curcumol is one of the major components of the essential oil of Rhizome Curcumae with the structure of sesquiterpenoid hemiketal. It exhibits characteristics such as antitumor, ant proliferation, anti-inflammatory, anti-hepatic fibrosis, antioxidant, and antimicrobial activities with low cytotoxicity. Curcumol suppresses the Breast Cancer Cells, Colorectal Cancer Cell Line, lung adenocarcinoma cell lines and others. However, its effect and mechanisms against tumor metastasis are still unclear. Recently was discovered a preliminary mechanism the suppression of breast cancer cell metastasis by curcumol. This mechanism suggested the inhibition of MMP-9 via JNK1/2 and Akt (Ser473)-dependent NF-κB signaling pathways.
Approval Year
Sample Use Guides
To explore the anti-cell proliferation mechanism of curcumol the changes of Jak2-STAT1/3 signal pathway-related molecules in synoviocytes were observed in vitro. In this study, the fibroblast-like synoviocytes (FLS) in patients with RA were collected and cultured. The following parameters were measured: cell proliferation (WST-1 assay in the presence of different concentrations of curcumol: 25, 50, 100, 200, 400, and 800 g/mL), cell cycles (fluorescence-activated cell sorting, FACS in the presence of different concentration of curcumol: 25, 50, 100 g/mL), STAT1 and STAT3 activities (electrophoretic mobility shift assay, EMSA), and the protein expressions of phosphorylated Jak2, STAT1, and STAT3 (Western blot). It was shown, that certain concentration of curcumol ranging from 25 g/mL to 100 g/mL could inhibit the RA-FLS proliferation and DNA synthesis induced by PDGF-BB in a dose-dependent manner in vitro. The fibroblast-like synoviocytes (FLS)
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14240392
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9190RTN07X
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4871-97-0
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DTXSID50964108
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admin on Sat Dec 16 02:30:38 GMT 2023 , Edited by admin on Sat Dec 16 02:30:38 GMT 2023
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SUBSTANCE RECORD
