Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C6H8O8 |
Molecular Weight | 208.1229 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O[C@H](C(O)=O)[C@@](O)(CC(O)=O)C(O)=O
InChI
InChIKey=ZMJBYMUCKBYSCP-CVYQJGLWSA-N
InChI=1S/C6H8O8/c7-2(8)1-6(14,5(12)13)3(9)4(10)11/h3,9,14H,1H2,(H,7,8)(H,10,11)(H,12,13)/t3-,6+/m1/s1
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: P53396 Gene ID: 47.0 Gene Symbol: ACLY Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11754536 |
PubMed
Title | Date | PubMed |
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[Effect of serum and osmotically active substances on metabolism in 262 tissue cultures of pig's corneas--improved preservation of donor tissue for keratoplasty]. | 2001 Feb |
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Hibiscus acid as an inhibitor of starch digestion in the Caco-2 cell model system. | 2001 Sep |
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Short-term (-)-hydroxycitrate ingestion increases fat oxidation during exercise in athletes. | 2002 Apr |
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Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. | 2002 Jan 2 |
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Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). | 2002 Sep |
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Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. | 2003 Dec |
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(-)-Hydroxycitric acid ingestion increases fat utilization during exercise in untrained women. | 2003 Jun |
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Modern, new pharmacotherapy for obesity. A gastrointestinal approach. | 2004 Dec |
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Common dietary supplements for weight loss. | 2004 Nov 1 |
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A perspective on the current strategies for the treatment of obesity. | 2004 Oct |
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Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. | 2004 Oct |
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Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. | 2004 Sep |
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Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control. | 2005 |
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Hydroxycitric acid delays intestinal glucose absorption in rats. | 2005 Jun |
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High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. | 2005 Mar |
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Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. | 2005 Nov 11 |
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[In vitro chromosome aberration test and in vivo micronucleus test of Ca-type Garcinia extract]. | 2006 Apr |
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Absolute configuration of hydroxycitric acid produced by microorganisms. | 2006 Aug |
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Effect of food deprivation and hormones of glucose homeostasis on the acetyl CoA carboxylase activity in mouse brain: a potential role of acc in the regulation of energy balance. | 2006 Feb 16 |
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Comparison of the effects of three different (-)-hydroxycitric acid preparations on food intake in rats: response. | 2006 Jul 17 |
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Effects of (-)-hydroxycitrate on net fat synthesis as de novo lipogenesis. | 2006 Jul 30 |
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Beneficial and deleterious effects of hydroxycitrate in rats fed a high-fructose diet. | 2006 Sep |
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Exploiting hypoxia in solid tumors to achieve oncolysis. | 2007 |
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Effects of ingesting JavaFit Energy Extreme functional coffee on aerobic and anaerobic fitness markers in recreationally-active coffee consumers. | 2007 Dec 8 |
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Genome shuffling of Streptomyces sp. U121 for improved production of hydroxycitric acid. | 2007 Jan |
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Chemistry, physiological properties, and microbial production of hydroxycitric acid. | 2007 Jul |
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Therapeutic efficacy and safety of undenatured type-II collagen (UC-II) alone or in combination with (-)-hydroxycitric acid and chromemate in arthritic dogs. | 2007 Jun |
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Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. | 2007 Mar 1 |
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Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. | 2007 Oct |
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Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement. | 2007 Sep |
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Beta-glucans in the treatment of diabetes and associated cardiovascular risks. | 2008 |
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Interaction of Aqueous Extract of Pleurotus pulmonarius (Fr.) Quel-Champ. with Glyburide in Alloxan Induced Diabetic Mice. | 2008 Jun |
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Body circumferences: clinical implications emerging from a new geometric model. | 2008 Oct 6 |
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Effect of Hibiscus sabdariffa L. dried calyx ethanol extract on fat absorption-excretion, and body weight implication in rats. | 2009 |
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Acute effects of pharmacological modifications of fatty acid metabolism on human satiety. | 2009 Jun |
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A change-point regression approach for efficacy evaluation of dietary supplements. | 2009 May |
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Glycation of aspartate aminotransferase by methylglyoxal, effect of hydroxycitric and uric acid. | 2009 Nov |
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Aqueous extract of garcinia indica choisy restores glutathione in type 2 diabetic rats. | 2010 Jul |
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Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment. | 2010 Jul 16 |
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Maitake mushroom extracts ameliorate progressive hypertension and other chronic metabolic perturbations in aging female rats. | 2010 Jun 7 |
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A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results. | 2010 May |
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Safety assessment of a calcium-potassium salt of (-)-hydroxycitric acid. | 2010 Nov |
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Meta-analysis for the effect of medical therapy vs. placebo on recovery of idiopathic sudden hearing loss. | 2010 Sep |
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Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice. | 2012 Aug |
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DSLD |
2324 (Number of products:70)
Created by
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Code System | Code | Type | Description | ||
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C007999
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HYDROXYCITRIC ACID
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185620
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1312602
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m6131
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100000125898
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DTXSID80863711
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SUB33094
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8W94T9026R
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8W94T9026R
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6205-14-7
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NON-SPECIFIC STEREOCHEMISTRY | |||
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27750-10-3
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)