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Details

Stereochemistry ACHIRAL
Molecular Formula C22H30N2O3
Molecular Weight 370.4852
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DAVASAICIN

SMILES

COC1=CC(CC(=O)NCCCC2=CC=C(C)C(C)=C2)=CC=C1OCCN

InChI

InChIKey=VVMIHZHLNJMAQP-UHFFFAOYSA-N
InChI=1S/C22H30N2O3/c1-16-6-7-18(13-17(16)2)5-4-11-24-22(25)15-19-8-9-20(27-12-10-23)21(14-19)26-3/h6-9,13-14H,4-5,10-12,15,23H2,1-3H3,(H,24,25)

HIDE SMILES / InChI
Davasaicin is a synthetic derivative of capsaicin, developed at the Korea Research Institute of Chemical Technology. Davasaicin possesses very potent analgesic activity, demonstrated in several animal models, such as phenylbenzoquinone-induced writhing test, tail-flick test in mice and adjuvant arthritic flexion test in rats. When administered topically, davasaicin has an antipruritic effect in the mouse model.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
589.0 nM [EC50]
Name Type Language
DAVASAICIN
INN  
INN  
Official Name English
DA-5018 FREE BASE
Code English
2-(4-(2-AMINOETHOXY)-3-METHOXYPHENYL)-N-(3-(3,4-DIMETHYLPHENYL)PROPYL)ACETAMIDE
Systematic Name English
davasaicin [INN]
Common Name English
KR-25018
Code English
Classification Tree Code System Code
NCI_THESAURUS C241
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
Code System Code Type Description
INN
8550
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
PRIMARY
EPA CompTox
DTXSID40163729
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
PRIMARY
PUBCHEM
177287
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
PRIMARY
FDA UNII
8V3419G4NR
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
PRIMARY
NCI_THESAURUS
C83652
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
PRIMARY
SMS_ID
300000034166
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
PRIMARY
CAS
147497-64-1
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
PRIMARY
ChEMBL
CHEMBL328628
Created by admin on Sat Dec 16 18:02:05 GMT 2023 , Edited by admin on Sat Dec 16 18:02:05 GMT 2023
PRIMARY