SODIUM IOXITHALAMATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H10I3N2O5.Na
Molecular Weight	665.9214
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CC(=O)NC1=C(I)C(C([O-])=O)=C(I)C(C(=O)NCCO)=C1I

InChI

InChIKey=PZTAFRMXSAAHMQ-UHFFFAOYSA-M

InChI=1S/C12H11I3N2O5.Na/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22;/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22);/q;+1/p-1

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Description
Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf | http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf

Ioxitalamic acid is a contrast media, which was used as a meglumine salt under the name Telebrix for intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography). The drug is no longer available on the market.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Urinary system disease 13 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cerebrovascular diseases 9 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Cardiovascular diseases 71 Sources: http://www.pharmaline.co.il/images/newsletterregistration/neopharm/23122011/telebrix35dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/19112012/telebrix12dr.pdf http://www.pharmaline.co.il/images/newsletterregistration/neopharm/promedico/16112012/telebrixdr.pdf	Diagnostic	Approved 8429	TELEBRIX Approved Use This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).

PubMed

Title	Date	PubMed
Telebrix: a better-tasting oral contrast agent for abdominal computed tomography.	1991 Apr	2039963
Telebrix Gastro in the management of adhesive small bowel obstruction.	2005 May	15980741
Computed microtomography visualization and quantification of mouse ischemic brain lesion by nonionic radio contrast agents.	2013 Feb	23444240
Do intravenous N-acetylcysteine and sodium bicarbonate prevent high osmolal contrast-induced acute kidney injury? A randomized controlled trial.	2014	25254489
Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro.	2016 Jan	26573558

Patents

Sample Use Guides

In Vivo Use Guide

The recommended doses are 1.0 ml/kg (Intravenous urography); 1 and 1.8 ml/kg (computed tomography of brain and computed tomography of the whole body, respectively); 40 ml (ventriculography); 4-8 ml (coronary angiography). The solution for injection contains 350 mg iode/ml.

Route of Administration: Intravenous

In Vitro Use Guide

Ioxitalamic acid was added to human basophils and mast cells isolated from lung, skin, and heart tissue at concentration of 0.1 to 0.5 mol/L (Telebrix preparation). The drug induced histamine release from basophils and histamine and tryptase release from human heart mast cells.

Name

Type

Language

SODIUM IOXITHALAMATE

Common Name

English

Ioxitalamate sodium [WHO-DD]

Common Name

English

BENZOIC ACID, 3-(ACETYLAMINO)-5-(((2-HYDROXYETHYL)AMINO)CARBONYL)-2,4,6-TRIIODO-, SODIUM SALT (1:1)

Systematic Name

English

IOXITALAMATE SODIUM

Common Name

English

SODIUM IOXITALAMATE

Common Name

English

ISOPHTHALAMIC ACID, 5-ACETAMIDO-N-(2-HYDROXYETHYL)-2,4,6-TRIIODO-, MONOSODIUM SALT

Systematic Name

English

IOXITALAMIC ACID, SODIUM SALT

Common Name

English

BENZOIC ACID, 3-(ACETYLAMINO)-5-(((2-HYDROXYETHYL)AMINO)CARBONYL)-2,4,6-TRIIODO-, MONOSODIUM SALT

Systematic Name

English

TELEBRIX

Brand Name

English

Code System Code Type Description

PUBCHEM

23681171