AXELOPRAN SULFATE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H39N3O4.H2O4S
Molecular Weight	555.684
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(O)(=O)=O.NC(=O)C1=CC=CC(=C1)[C@@H]2C[C@@H]3CC[C@H](C2)N3CCN(CC4CCCCC4)C(=O)[C@@H](O)CO

InChI

InChIKey=QNFFAKFVKCGLPK-WTKDUOFSSA-N

InChI=1S/C26H39N3O4.H2O4S/c27-25(32)20-8-4-7-19(13-20)21-14-22-9-10-23(15-21)29(22)12-11-28(26(33)24(31)17-30)16-18-5-2-1-3-6-18;1-5(2,3)4/h4,7-8,13,18,21-24,30-31H,1-3,5-6,9-12,14-17H2,(H2,27,32);(H2,1,2,3,4)/t21-,22+,23-,24-;/m0./s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30289777 | https://clinicaltrials.gov/ct2/show/NCT01401985 | https://www.ncbi.nlm.nih.gov/pubmed/30289777

Axelopran (previously known as TD-1211), a peripherally selective, multivalent µ-opioid receptor antagonist that is under development by Theravance Biopharma. This drug participated in phase II clinical trials in subjects with opioid-induced constipation. The most common adverse events were abdominal pain, nausea, and diarrhea. There were no indications of opioid withdrawal effects or reductions in opioid analgesia in patients treated with axelopran.

Originator

Approval Year

PubMed

Title	Date	PubMed
Clinical Overview and Considerations for the Management of Opioid-induced Constipation in Patients With Chronic Noncancer Pain.	2019-02	30289777
Discovery of N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of μ-opioid receptor antagonists.	2017-07-01	28499731
Novel Oral Therapies for Opioid-induced Bowel Dysfunction in Patients with Chronic Noncancer Pain.	2016-03	26945548

Patents

Sample Use Guides

In Vivo Use Guide

Capsules once daily

Route of Administration: Oral

Name

Type

Language

AXELOPRAN SULFATE

Official Name

English

TD-1211 SULFATE

Preferred Name

English

3-[(1R,3R,5S)-8-(2-{(Cyclohexylmethyl)[(2S)-2,3-dihydroxypropanoyl]amino}ethyl)-8-azabicyclo[3.2.1]octan-3-yl]benzamide monosulfate

Systematic Name

English

Axelopran sulfate [WHO-DD]

Common Name

English

BENZAMIDE, 3-((3-ENDO)-8-(2-((CYCLOHEXYLMETHYL)((2S)-2,3-DIHYDROXY-1-OXOPROPYL)AMINO)ETHYL)-8-AZABICYCLO(3.2.1)OCT-3-YL)-, SULFATE (1:1)

Systematic Name

English

AXELOPRAN SULFATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C681