MORIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H10O7
Molecular Weight	302.2357
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC=C(C(O)=C1)C2=C(O)C(=O)C3=C(O)C=C(O)C=C3O2

InChI

InChIKey=YXOLAZRVSSWPPT-UHFFFAOYSA-N

InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Potency
CHEMBL3833502 (Alpha glucosidase) 1 Target ID: CHEMBL3833502 (Alpha glucosidase) Sources: https://www.ncbi.nlm.nih.gov/pubmed/27549567	Inhibitor 8297	4.48 µM [IC50]
Protein-tyrosine phosphatase 1B 34 Target ID: CHEMBL335 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23352912	Inhibitor 8297
Islet amyloid polypeptide 1 Target ID: CHEMBL1914266 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22238175	Inhibitor 8297
DNA-3-methyladenine glycosylase 1 Target ID: CHEMBL3396943 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25650313	Inhibitor 8297	2.6 µM [IC50]

PubMed

Title	Date	PubMed
Steroid hormone activity of flavonoids and related compounds.	2000 Jul	10989984
Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.	2000 Jul-Aug	10953322
Measurement of copper-binding sites on low density lipoprotein.	2001 Apr	11304478
Comparison of quercetin and a non-orthohydroxy flavonol as antioxidants by competing in vitro oxidation reactions.	2001 Jul	11453777
The inhibitory effects of pure flavonoids on in vitro protein glycosylation.	2002	15277096
Stability of green fluorescent protein using luminescence spectroscopy: is GFP applicable to field analysis of contaminants?	2002	12442776
Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol.	2002 Jan	11860745
Time resolved fluorescence spectroscopy of quercetin and morin complexes with Al3+.	2002 Jan 1	11808653
Ultrasound screening of the infant's hip: introduction of a new combined angle.	2002 Jul	12089496
Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.	2002 Mar 8	11809535
Recognition forces involved in mitochondrial binding to a low-affinity trimetazidine binding site related to anti-ischemic activity.	2002 May 1	12007572
Aluminium-induced growth inhibition is associated with impaired efflux and influx of H+ across the plasma membrane in root apices of squash (Cucurbita pepo).	2002 Sep	12177136
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.	2002 Sep 15	12069687
Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions.	2003 Feb	12631120
Clinical implementation of 4-dihydroxyborylphenylalanine synthesised by an asymmetric pathway.	2003 Feb	12594009
Effects of flavonoids on the susceptibility of low-density lipoprotein to oxidative modification.	2003 Jul	12878454
Determination of trace tin by solid substrate-room temperature phosphorimetry using sodium dodecyl sulfate as sensitizer.	2003 Jul	12788461
Pro-oxidative properties of flavonoids in human lymphocytes.	2003 Jun	12843645
Degradation of flavonoid aglycones by rabbit, rat and human fecal flora.	2003 May	12736527
Faculty matters. Karen H. Morin.	2003 Nov-Dec	14763452
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease.	2003 Oct	12969264
[Azoic color reaction of flavonoids and their analytical application].	2004 Aug	15766128
Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin.	2004 Aug	15305001
The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells.	2004 Aug 15	15276069
[Granuloma with lymphocytic hyperplasia following vaccination: 10 cases. Presence of aluminium in the biopsies].	2004 Aug-Sep	15505542
Free radicals scavenging efficiency of a few naturally occurring flavonoids: a comparative study.	2004 Dec 1	15563224
Variations and voids: the regulation of human cloning around the world.	2004 Dec 13	15596013
Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.	2004 Jan 9	14557274
Structural requirements of flavonoids for increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes.	2004 Jun	15279724
Absence of the TAP2 human recombination hotspot in chimpanzees.	2004 Jun	15208713
[Study on the fluorescence spectra of LaL3 with DNA].	2004 Mar	15759993
Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations.	2004 May	15133252
Inhibition of human low density lipoprotein oxidation by flavonols and their glycosides.	2004 May	15081861
Inhibition of free radical initiated peroxidation of human erythrocyte ghosts by flavonols and their glycosides.	2004 May 7	15105935
[Speciation of aluminum in natural waters by fluorimetry].	2004 Nov	15762485
Effects of morin on blood pressure and metabolic changes in fructose-induced hypertensive rats.	2004 Nov	15516722
[Studies on a new fluorescence-enhanced system of nucleic acids-morin-Al(III)].	2004 Oct	15760028
Flavone inhibition of tumor growth via apoptosis in vitro and in vivo.	2004 Sep	15289867
Investigation of dissolved uranium content in the watershed of Seine River (France).	2005	15465175
Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.	2005 Feb 15	15670588
G-protein signaling: back to the future.	2005 Mar	15747061
Flavonoids and tyrosine nitration: structure-activity relationship correlation with enthalpy of formation.	2005 Mar	15649628

Patents

Name

Type

Language

MORIN

Common Name

English

2'-HYDROXYPELARGIDENOLON 1522

Common Name

English

C.I. NATURAL YELLOW 8

Common Name

English

C.I. 75660

Common Name

English

2-(2,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-4H-1-BENZOPYRAN-4-ONE

Systematic Name

English

OSAGE ORANGE EXTRACT

Common Name

English

NSC-19801

Code

English

MORIN [MI]

Common Name

English

2',3,4',5,7-PENTAHYDROXYFLAVONE

Systematic Name

English

Code System Code Type Description

NSC

19801