DELSOLINE

Details

Stereochemistry	MIXED
Molecular Formula	C25H41NO7
Molecular Weight	467.5955
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 13
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C[C@]2(COC)CC[C@H](O)[C@@]34C5C[C@H]6[C@H](OC)C5[C@](O)(C[C@@H]6OC)[C@@](O)([C@@H](OC)C23)C14

InChI

InChIKey=JVBLTQQBEQQLEV-LPHVGPHASA-N

InChI=1S/C25H41NO7/c1-6-26-11-22(12-30-2)8-7-16(27)24-14-9-13-15(31-3)10-23(28,17(14)18(13)32-4)25(29,21(24)26)20(33-5)19(22)24/h13-21,27-29H,6-12H2,1-5H3/t13-,14?,15+,16+,17?,18+,19?,20+,21+,22+,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8941400 | https://www.scbt.com/scbt/product/delsoline-509-18-2

Delsoline is a Nicotinic receptor antagonist, ganglion blocker; exhibits weak affinity at brain α-bungarotoxin-sensitive nicotinic acetylcholine receptors.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Neuronal acetylcholine receptor subunit alpha-7 14 Target ID: Q05941 Gene ID: 25302.0 Gene Symbol: Chrna7 Target Organism: Rattus norvegicus (Rat) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8941400	Antagonist 2778		19.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3158157	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Norditerpene and diterpene alkaloids from Aconitum variegatum.	2005 Apr	15797610
Diterpenoid Alkaloids from Consolida regalis S. F.Gray subsp.paniculata (Host) Soo var. paniculata.	2017 Aug 16	28813032

Patents

Sample Use Guides

In Vivo Use Guide

Intraperitoneal delsoline, at doses of 1.25–2.5 mg/kg in dogs or 10 mg/kg in rats, had a hypotensive effect.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Delsoline inhibited [125I]-aBgTX binding in rat brain membranes with an IC50 of 19 uM.

Name

Type

Language

DELSOLINE

Common Name

English

18-O-METHYLGIGACTONINE

Common Name

English

ACONITANE-1,7,8-TRIOL, 20-ETHYL-6,14,16-TRIMETHOXY-4-(METHOXYMETHYL)-, (1.ALPHA.,6.BETA.,14.ALPHA.,16.BETA.)-

Common Name

English

DELSOLINE [MI]

Common Name

English

ACOMONINE

Common Name

English

Code System Code Type Description

PUBCHEM

44655937