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Details

Stereochemistry MIXED
Molecular Formula C25H41NO7
Molecular Weight 467.5955
Optical Activity UNSPECIFIED
Defined Stereocenters 10 / 13
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DELSOLINE

SMILES

CCN1C[C@]2(COC)CC[C@H](O)[C@@]34C5C[C@H]6[C@H](OC)C5[C@](O)(C[C@@H]6OC)[C@@](O)([C@@H](OC)C23)C14

InChI

InChIKey=JVBLTQQBEQQLEV-LPHVGPHASA-N
InChI=1S/C25H41NO7/c1-6-26-11-22(12-30-2)8-7-16(27)24-14-9-13-15(31-3)10-23(28,17(14)18(13)32-4)25(29,21(24)26)20(33-5)19(22)24/h13-21,27-29H,6-12H2,1-5H3/t13-,14?,15+,16+,17?,18+,19?,20+,21+,22+,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Molecular Formula C25H41NO7
Molecular Weight 467.5955
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 10 / 13
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Delsoline is a Nicotinic receptor antagonist, ganglion blocker; exhibits weak affinity at brain α-bungarotoxin-sensitive nicotinic acetylcholine receptors.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
19.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Intraperitoneal delsoline, at doses of 1.25–2.5 mg/kg in dogs or 10 mg/kg in rats, had a hypotensive effect.
Route of Administration: Intraperitoneal
In Vitro Use Guide
Delsoline inhibited [125I]-aBgTX binding in rat brain membranes with an IC50 of 19 uM.
Substance Class Chemical
Record UNII
8NCS5NCP4W
Record Status Validated (UNII)
Record Version