DELSOLINE

Details

Stereochemistry	MIXED
Molecular Formula	C25H41NO7
Molecular Weight	467.5955
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 13
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C[C@]2(COC)CC[C@H](O)[C@@]34C5C[C@H]6[C@H](OC)C5[C@](O)(C[C@@H]6OC)[C@@](O)([C@@H](OC)C23)C14

InChI

InChIKey=JVBLTQQBEQQLEV-LPHVGPHASA-N

InChI=1S/C25H41NO7/c1-6-26-11-22(12-30-2)8-7-16(27)24-14-9-13-15(31-3)10-23(28,17(14)18(13)32-4)25(29,21(24)26)20(33-5)19(22)24/h13-21,27-29H,6-12H2,1-5H3/t13-,14?,15+,16+,17?,18+,19?,20+,21+,22+,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H41NO7
Molecular Weight	467.5955
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	10 / 13
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8941400 | https://www.scbt.com/scbt/product/delsoline-509-18-2

Delsoline is a Nicotinic receptor antagonist, ganglion blocker; exhibits weak affinity at brain α-bungarotoxin-sensitive nicotinic acetylcholine receptors.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Neuronal acetylcholine receptor subunit alpha-7 14 Target ID: Q05941 Gene ID: 25302.0 Gene Symbol: Chrna7 Target Organism: Rattus norvegicus (Rat) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8941400	Antagonist 2778		19.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3158157	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Intraperitoneal delsoline, at doses of 1.25–2.5 mg/kg in dogs or 10 mg/kg in rats, had a hypotensive effect.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Delsoline inhibited [125I]-aBgTX binding in rat brain membranes with an IC50 of 19 uM.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:48:19 GMT 2023` Edited by `admin` on `Sat Dec 16 09:48:19 GMT 2023`
Record UNII	8NCS5NCP4W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DELSOLINE

Common Name

English

18-O-METHYLGIGACTONINE

Common Name

English

ACONITANE-1,7,8-TRIOL, 20-ETHYL-6,14,16-TRIMETHOXY-4-(METHOXYMETHYL)-, (1.ALPHA.,6.BETA.,14.ALPHA.,16.BETA.)-

Common Name

English

DELSOLINE [MI]

Common Name

English

ACOMONINE

Common Name

English

Code System Code Type Description

PUBCHEM

44655937