Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C8H16N2O3 |
| Molecular Weight | 188.2242 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C[C@H](NC(=O)CN)C(O)=O
InChI
InChIKey=DKEXFJVMVGETOO-LURJTMIESA-N
InChI=1S/C8H16N2O3/c1-5(2)3-6(8(12)13)10-7(11)4-9/h5-6H,3-4,9H2,1-2H3,(H,10,11)(H,12,13)/t6-/m0/s1
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q96KP4 Gene ID: 55748.0 Gene Symbol: CNDP2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/13757377 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Development of biodegradable polyurethane scaffolds using amino acid and dipeptide-based chain extenders for soft tissue engineering. | 2010 |
|
| [Digestive enzyme activities in rats kept on standard or surplus breast-feeding and on low-protein diet directly after weaning]. | 2009-07-03 |
|
| [Evaluation of the role of the peptide transport system in absorption of dipeptides in the rat small intestine in chronic experiments in vivo]. | 2009-05-14 |
|
| Equilibrium and kinetic investigations of the interaction of model platinum(II) complex with DNA constituents in reference to the antitumour activity: complex-formation reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with ligands of biological significance and displacement reactions of DNA constituents. | 2009 |
|
| [Effect of weaning terms and protein deficit in the rat pup nutrition on activities of digestive enzymes]. | 2008-10-31 |
|
| Delayed effects of the terms of separation of rat pups from lactating females and low-protein diet on enzyme activity in digestive and non-digestive organs. | 2008-06 |
|
| Folded structures of L-leucylglycine oligopeptides and their aggregational behavior in aqueous solution: Raman scattering spectra and proton NMR spin-lattice relaxation studies. | 2008-05-08 |
|
| Hexaaqua-cadmium(II) bis-{[N-(2-oxidobenzyl-idene)glycyl-l-leucinato]cuprate(II)} dihydrate. | 2007-12-06 |
|
| Characterization of Gly-D-Phe, Gly-L-Leu, and D-Phe as affinity ligands to thermolysin. | 2006-04 |
|
| The yeaS (leuE) gene of Escherichia coli encodes an exporter of leucine, and the Lrp protein regulates its expression. | 2005-08-29 |
|
| Transpeptidation reactions of a specific substrate catalyzed by the streptomyces R61 DD-peptidase: characterization of a chromogenic substrate and acyl acceptor design. | 2005-08-02 |
|
| Transpeptidation reactions of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase: the structural basis of acyl acceptor specificity. | 2005-08-02 |
|
| New triorganotin(IV) derivatives of dipeptides as anti-inflammatory-antimicrobial agents. | 2005-03 |
|
| Relationship between protein deficiency in the ration of rats during early ontogeny and function of enzyme systems of digestive and non-digestive organs in adult life. | 2004-07 |
|
| Temperature dependent characteristics of intestinal glycyl-L-leucine dipeptidase in boreal zone fish. | 2003-10 |
|
| Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats. | 2002-12 |
|
| In vitro and in situ evidence for the contribution of Labrasol and Gelucire 44/14 on transport of cephalexin and cefoperazone by rat intestine. | 2002-11 |
|
| Copper(II)- cis, cis-1,3,5-triaminocyclohexane complex-promoted hydrolysis of dipeptides: kinetic, speciation and structural studies. | 2002-09 |
|
| [Digestive system status after prolonged space flights]. | 1982-03-01 |
|
| Gas-chromatographic/mass-spectrometric identification and quantitation of tetronic and deoxytetronic acids in urine from normal adults and neonates. | 1975-12 |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2754839
Curator's Comment: The uptake of L-leucylglycine into intestinal brush border membrane vesicles isolated from rats was investigated. hey were fed either oligopeptide (SP group) or amino acid (AA group) elemental diets for four weeks. In case of L-leucylglycine uptake, there was no difference in Km value between the two groups, but Jmax value of SP group is significantly about twice as large as that of AA group. There is however, no difference in Km value and Jmax value between the both groups. These results indicate that L-leucylglycine transport carriers in the brush border membrane significantly increased in SP group compared with that in AA group, and that these carriers might be induced by oligopeptides as intraintestinal substrate.
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SUBSTANCE RECORD