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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H13NO4
Molecular Weight 211.2145
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHYLDOPA, D-

SMILES

C[C@@](N)(CC1=CC=C(O)C(O)=C1)C(O)=O

InChI

InChIKey=CJCSPKMFHVPWAR-SNVBAGLBSA-N
InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m1/s1

HIDE SMILES / InChI
D-Methyldopa is an inactive isomer of methyldopa. It is known, that only L-isomer has the ability to inhibit dopa decarboxylase and possesses the antihypertensive activity in man. Moreover, about twice the dose of the racemate (DL-form of methyldopa) is required for the equal antihypertensive effect.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Direct high-performance liquid chromatographic determination of the enantiomeric purity of levodopa and methyldopa: comparison with pharmacopoeial polarimetric methods.
1999 Mar
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
METHYLDOPA, D-
Common Name English
D-.ALPHA.-METHYLDOPA
Common Name English
D-(3,4-DIHYDROXYPHENYL)-2-METHYLALANINE
Common Name English
METHYLDOPA ANHYDROUS, D-
Common Name English
D-TYROSINE, 3-HYDROXY-.ALPHA.-METHYL-
Systematic Name English
D-METHYLDOPA
Common Name English
(2R)-2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYLPROPANOIC ACID
Systematic Name English
IMT-002
Code English
METHYLDOPA IMPURITY D [EP IMPURITY]
Common Name English
(+)-.ALPHA.-METHYLDOPA
Common Name English
D-.ALPHA.-METHYL-3-(3,4-DIHYDROXYPHENYL)ALANINE
Common Name English
Code System Code Type Description
CLINICAL_TRIALS.GOV
NCT00976235
Created by admin on Sat Dec 16 08:04:59 GMT 2023 , Edited by admin on Sat Dec 16 08:04:59 GMT 2023
PRIMARY
EPA CompTox
DTXSID50859484
Created by admin on Sat Dec 16 08:04:59 GMT 2023 , Edited by admin on Sat Dec 16 08:04:59 GMT 2023
PRIMARY
FDA UNII
8K91SZC8W9
Created by admin on Sat Dec 16 08:04:59 GMT 2023 , Edited by admin on Sat Dec 16 08:04:59 GMT 2023
PRIMARY
CAS
2799-15-7
Created by admin on Sat Dec 16 08:04:59 GMT 2023 , Edited by admin on Sat Dec 16 08:04:59 GMT 2023
PRIMARY
PUBCHEM
721860
Created by admin on Sat Dec 16 08:04:59 GMT 2023 , Edited by admin on Sat Dec 16 08:04:59 GMT 2023
PRIMARY