CLOPIDOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H7Cl2NO
Molecular Weight	192.043
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC(C)=C(Cl)C(O)=C1Cl

InChI

InChIKey=ZDPIZLCVJAAHHR-UHFFFAOYSA-N

InChI=1S/C7H7Cl2NO/c1-3-5(8)7(11)6(9)4(2)10-3/h1-2H3,(H,10,11)

HIDE SMILES / InChI

Description
Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM388189.pdf

Clopidol is an anticoccidial drug used in chickens and turkeys in oredr to prevent coccidiosis and leucocytozoonosis. The drug is approved by FDA and is marketed under the names Coyden 25 and Lerbek 25 (in combination with methylbenzoquate).

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM388189.pdf	Preventing		Approved 8583	COYDEN 25 Approved Use Chickens: Aid in the prevention of coccidiosis caused by E. tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati. Turkeys: Aid in the prevention of leucocytozoonosis caused by Leucocytozoon smithi. Launch Date 1997
Leucocytozoonosis 1 Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM388189.pdf	Preventing		Approved 8583	COYDEN 25 Approved Use Chickens: Aid in the prevention of coccidiosis caused by E. tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati. Turkeys: Aid in the prevention of leucocytozoonosis caused by Leucocytozoon smithi. Launch Date 1997

PubMed

Title	Date	PubMed
Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.	2013-06-13	23701465
Development and validation of a rapid multi-class method for the confirmation of fourteen prohibited medicinal additives in pig and poultry compound feed by liquid chromatography-tandem mass spectrometry.	2010-12-01	20643524
Is implantation of drug-eluting stents a Faustian choice?	2010-10	20944184
Incidence, predictors and outcome of drug-eluting stent thrombosis in real-world practice.	2010-10	20944183
Determination of residual clopidol in chicken muscle by capillary gas chromatography-negative chemical ionization-mass spectrometry.	2009-10	19822963
Sensitivity of isolates of Eimeria from turkey flocks to the anticoccidial drugs amprolium, clopidol, diclazuril, and monensin.	2009-09	19848080
[Determination of clopidol residue in poultry products by liquid chromatography-electrospray ion trap tandem mass spectrometry].	2009-03	19626838
[Determination of clopidol residues in chicken muscle by gas chromatography-mass spectrometry].	2009-01	19449548
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.	2008-05-08	18396855
Antimalarial quinolones: synthesis, potency, and mechanistic studies.	2008-04	18082162
ACTIVE-W: warfarin beats clopidogrel/aspirin in atrial fibrillation.	2006-05-31	16733604
Relative virulences of a drug-resistant and a drug-sensitive strain of Eimeria acervulina, a coccidium of chickens.	2006-01-15	16361061
Determination of residual clopidol in chicken muscle by capillary gas chromatography/mass spectrometry.	2005-09-13	16152927
Determination of clopidol residues in chicken tissues by liquid chromatography: collaborative study.	2003-09-26	14509425
Efficacy of selected oral chemotherapeutants against Ichthyophthirius multifiliis (Ciliophora: Ophyroglenidae) infecting rainbow trout Oncorhynchus mykiss.	2003-06-20	12887250
Committee on drugs and related topics. Drug residues in animal tissues.	2003-02-28	12607749
Comparison of ion-pairing and ion-suppressing liquid chromatographic methods for the determination of pyrimethamine and ormetoprim in chicken feed.	2002-07	12137205
Effect of clopidogrel on platelet aggregation and plasma concentration of fibrinogen in subjects with cerebral or coronary atherosclerotic disease.	2002-04	12121059
Determination of clopidol residues in chicken tissues by liquid chromatography: part III. Quality control analysis of export chickens.	2001-10-17	11601452
Determination of clopidol residues in chicken tissues by liquid chromatography: part II. Distribution and depletion of clopidol in chicken tissues.	2001-10-17	11601451
Determination of clopidol residues in chicken tissues by liquid chromatography: part I. Optimization of analytical conditions and comparison with AOAC gas chromatography method.	2001-10-17	11601450

Patents

Sample Use Guides

In Vivo Use Guide

For preventing coccidiosis in broiler chickens and chickens reared for laying blend 500 g of 25% formulation (Coyden 25) per ton of feed. To prevent leucocytozoonosis in turkeys use 125 to 250 grams per ton of feed. The final concentration should not exceed 250 ppm.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

NSC-253479

Preferred Name

English

CLOPIDOL

Official Name

English

CLOPIDOL [USAN]

Common Name

English

clopidol [INN]

Common Name

English

CLOPIDOL [GREEN BOOK]

Common Name

English

3,5-Dichloro-2,6-dimethyl-4-pyridinol

Systematic Name

English

4-PYRIDINOL, 3,5-DICHLORO-2,6-DIMETHYL-

Systematic Name

English

CLOPIDOL [MART.]

Common Name

English

CLOPIDOL [MI]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 558.175