CLOPIDOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H7Cl2NO
Molecular Weight	192.043
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC(C)=C(Cl)C(O)=C1Cl

InChI

InChIKey=ZDPIZLCVJAAHHR-UHFFFAOYSA-N

InChI=1S/C7H7Cl2NO/c1-3-5(8)7(11)6(9)4(2)10-3/h1-2H3,(H,10,11)

HIDE SMILES / InChI

Description
Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM388189.pdf

Clopidol is an anticoccidial drug used in chickens and turkeys in oredr to prevent coccidiosis and leucocytozoonosis. The drug is approved by FDA and is marketed under the names Coyden 25 and Lerbek 25 (in combination with methylbenzoquate).

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM388189.pdf	Preventing		Approved 8429	COYDEN 25 Approved Use Chickens: Aid in the prevention of coccidiosis caused by E. tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati. Turkeys: Aid in the prevention of leucocytozoonosis caused by Leucocytozoon smithi. Launch Date 1997
Leucocytozoonosis 1 Sources: http://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM388189.pdf	Preventing		Approved 8429	COYDEN 25 Approved Use Chickens: Aid in the prevention of coccidiosis caused by E. tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mivati. Turkeys: Aid in the prevention of leucocytozoonosis caused by Leucocytozoon smithi. Launch Date 1997

PubMed

Title	Date	PubMed
Determination of clopidol residues in chicken tissues by liquid chromatography: part II. Distribution and depletion of clopidol in chicken tissues.	2001 Sep-Oct	11601451
Determination of clopidol residues in chicken tissues by liquid chromatography: part I. Optimization of analytical conditions and comparison with AOAC gas chromatography method.	2001 Sep-Oct	11601450
Effect of clopidogrel on platelet aggregation and plasma concentration of fibrinogen in subjects with cerebral or coronary atherosclerotic disease.	2002 Apr	12121059
Comparison of ion-pairing and ion-suppressing liquid chromatographic methods for the determination of pyrimethamine and ormetoprim in chicken feed.	2002 Jul	12137205
Determination of residual clopidol in chicken muscle by capillary gas chromatography/mass spectrometry.	2005 Jul-Aug	16152927
ACTIVE-W: warfarin beats clopidogrel/aspirin in atrial fibrillation.	2006 Mar-Apr	16733604
Determination of residual clopidol in chicken muscle by capillary gas chromatography-negative chemical ionization-mass spectrometry.	2009 Oct	19822963
Sensitivity of isolates of Eimeria from turkey flocks to the anticoccidial drugs amprolium, clopidol, diclazuril, and monensin.	2009 Sep	19848080
Is implantation of drug-eluting stents a Faustian choice?	2010 Oct	20944184
Incidence, predictors and outcome of drug-eluting stent thrombosis in real-world practice.	2010 Oct	20944183
Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.	2013 Jun 13	23701465

Patents

Sample Use Guides

In Vivo Use Guide

For preventing coccidiosis in broiler chickens and chickens reared for laying blend 500 g of 25% formulation (Coyden 25) per ton of feed. To prevent leucocytozoonosis in turkeys use 125 to 250 grams per ton of feed. The final concentration should not exceed 250 ppm.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

CLOPIDOL

Official Name

English

CLOPIDOL [USAN]

Common Name

English

clopidol [INN]

Common Name

English

CLOPIDOL [GREEN BOOK]

Common Name

English

3,5-Dichloro-2,6-dimethyl-4-pyridinol

Systematic Name

English

4-PYRIDINOL, 3,5-DICHLORO-2,6-DIMETHYL-

Systematic Name

English

CLOPIDOL [MART.]

Common Name

English

CLOPIDOL [MI]

Common Name

English

NSC-253479

Code

English

Classification Tree Code System Code

CFR

21 CFR 558.175