D&C GREEN NO. 5

First approved in 1963

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H20N2O8S2.2Na
Molecular Weight	622.577
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].CC1=CC=C(NC2=CC=C(NC3=C(C=C(C)C=C3)S([O-])(=O)=O)C4=C2C(=O)C5=CC=CC=C5C4=O)C(=C1)S([O-])(=O)=O

InChI

InChIKey=FPAYXBWMYIMERV-UHFFFAOYSA-L

InChI=1S/C28H22N2O8S2.2Na/c1-15-7-9-19(23(13-15)39(33,34)35)29-21-11-12-22(30-20-10-8-16(2)14-24(20)40(36,37)38)26-25(21)27(31)17-5-3-4-6-18(17)28(26)32;;/h3-14,29-30H,1-2H3,(H,33,34,35)(H,36,37,38);;/q;2*+1/p-2

HIDE SMILES / InChI

Description
Sources: https://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_009.pdf
Curator's Comment: description was created based on several sources, including https://www.drugs.com/inactive/d-c-green-no-5-354.html | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=74.2205 | https://www.ncbi.nlm.nih.gov/pubmed/25145135 | https://www.ncbi.nlm.nih.gov/pubmed/1697740 | https://www.ncbi.nlm.nih.gov/pubmed/2038271

D&C Green No. 5 is an FDA-approved, synthetic dye produced from petroleum or coal tar sources, that used in pharmaceuticals and cosmetics. D&C Green No. 5 may be safely used for coloring drugs and surgical sutures. In cosmetics, it can be used externally and in general cosmetics, including lipsticks, and cosmetics close to the eye.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Envelope glycoprotein gp160 2 Target ID: CHEMBL5826 Sources: http://journals.sagepub.com/doi/abs/10.1177/095632029200300107	Inhibitor 8297		60.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
HIV-1 infection 151 Sources: DOI: 10.1177/095632029200300107	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Qualitative identification of permitted and non-permitted color additives in cosmetics.	2014 Jul-Aug	25145135
Simultaneous removal of acid green 25 and mercury ions from aqueous solutions using glutamine modified chitosan magnetic composite microspheres.	2016 Feb	26618263

Patents

Sample Use Guides

In Vivo Use Guide

The 13 week oral toxicity study in rats revealed a NOEL of 100 mg/kg bw/day

Route of Administration: Oral

In Vitro Use Guide

D&C Green No. 5 activity was evaluated against human immunodeficiency virus type 1 (HIV-1) in primary human lymphocytes. The antiviral assays were conducted in mitogen stimulated human PBMC infected with HIV-1 (strain LAV). Stock solutions of the drugs were prepared in DMSO and diluted so that the final concentration of DMSO in the medium did not exceed 0.05%. The D&C Green No. 5 were added about 45 min after infection. Six days later when virus production was at a maximum, the supernatant was clarified and the virus concentrated by high speed centrifugation. The reverse transcriptase activity associated with the disrupted virus was determined. The virus infected control had about 3 x 105 decompositions per minute per ml of reverse transcriptase activity. The blank and uninfected cell control values were about 500 and 1200 dpm, respectively

Name

Type

Language

D&C GREEN NO. 5

Common Name

English

ACID GREEN 25

Official Name

English

D & C GREEN #5 [VANDF]

Common Name

English

MIDORI201

Official Name

English

NSC-7795

Code

English

CI 61570

Official Name

English

D & C GREEN NO. 5

Common Name

English

DC GREEN NO. 5

Common Name

English

ACID GREEN 25, C.I. NO. 61570

Common Name

English

COVACAP VERT W 7103

Brand Name

English

ALIZARIN CYANINE GREEN F [MI]

Common Name

English

ACID GREEN 25 [INCI]

Common Name

English

D&C GREEN NO. 5 [II]

Common Name

English

CI 61570 [INCI]

Common Name

English

MIDORI201 [INCI]

Common Name

English

NSC-41838

Code

English

GREEN 5 [INCI]

Common Name

English

GREEN 5

Official Name

English

VIBRACOLOR GREEN AGR5

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C461