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Description
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/?term=25069859

Technetium (99mTc) tilmanocept, trade name Lymphoseek, is a radiopharmaceutical diagnostic imaging agent approved for the imaging of lymph nodes. It is used to locate those lymph nodes which may be draining from tumors, and assist doctors in locating those lymph nodes for removal during surgery.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P22897
Gene ID: 4360.0
Gene Symbol: MRC1
Target Organism: Homo sapiens (Human)
27.6 pM [Kd]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
LYMPHOSEEK

Approved Use

A radioactive diagnostic agent indicated with or without scintigraphic imaging for lymphatic mapping using a handheld gamma counter to locate lymph nodes draining a primary tumor site in patients with solid tumors for which this procedure is a component of intraoperative management; Guiding sentinel lymph node biopsy using a handheld gamma counter in patients with clinically node negative squamous cell carcinoma of the oral cavity, breast cancer or melanoma

Launch Date

2013
Diagnostic
LYMPHOSEEK

Approved Use

A radioactive diagnostic agent indicated with or without scintigraphic imaging for lymphatic mapping using a handheld gamma counter to locate lymph nodes draining a primary tumor site in patients with solid tumors for which this procedure is a component of intraoperative management; Guiding sentinel lymph node biopsy using a handheld gamma counter in patients with clinically node negative squamous cell carcinoma of the oral cavity, breast cancer or melanoma.

Launch Date

2013
Diagnostic
LYMPHOSEEK

Approved Use

A radioactive diagnostic agent indicated with or without scintigraphic imaging for lymphatic mapping using a handheld gamma counter to locate lymph nodes draining a primary tumor site in patients with solid tumors for which this procedure is a component of intraoperative management; Guiding sentinel lymph node biopsy using a handheld gamma counter in patients with clinically node negative squamous cell carcinoma of the oral cavity, breast cancer or melanoma

Launch Date

2013
PubMed

PubMed

TitleDatePubMed
Less is better? Intraindividual and interindividual comparison between 0.075 mmol/kg of gadobenate dimeglumine and 0.1 mmol/kg of gadoterate meglumine for cranial MRI.
2014 Jul

Sample Use Guides

Administer 18.5 MBq (0.5 mCi) of Lymphoseek at least 15 minutes before initiating intraoperative lymphatic mapping. Complete lymphatic mapping within 15 hours of Lymphoseek injection. Recommended administration routes are intradermal, subcutaneous, and peritumoral injections. Each radiolabled Lymphoseek vial contains sufficient amount to provide doses for up to four patients when prepared according to the instructions. The radiolabeled Lymphoseek is to be used within 6 hours of its preparation.
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
TECHNETIUM TC-99M TILMANOCEPT
ORANGE BOOK  
Common Name English
TECHNETIUM TC 99M TILMANOCEPT [USAN]
Common Name English
LYMPHOSEEK
Brand Name English
TECHNETIUM TC 99M TILMANOCEPT
USAN   WHO-DD  
USAN  
Official Name English
TECHNETIUM TC 99M TILMANOCEPT [MI]
Common Name English
1600
Code English
Technetium Tc 99m tilmanocept [WHO-DD]
Common Name English
TECHNETIUM TC-99M TILMANOCEPT [ORANGE BOOK]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 427814
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NDF-RT N0000177914
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WHO-ATC V09IA09
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Code System Code Type Description
NCI_THESAURUS
C77898
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PRIMARY
MERCK INDEX
m11727
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PRIMARY
WIKIPEDIA
Technetium (99mTc) tilmanocept
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PRIMARY
LACTMED
Technetium Tc 99m Tilmanocept
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PRIMARY
CAS
1262984-82-6
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PRIMARY
DAILYMED
8IHI69PQTC
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PRIMARY
DRUG CENTRAL
4755
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PRIMARY
SMS_ID
300000044517
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PRIMARY
ChEMBL
CHEMBL2108726
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PRIMARY
DRUG BANK
DB09266
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PRIMARY
USAN
XX-68
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PRIMARY
FDA UNII
8IHI69PQTC
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PRIMARY
EPA CompTox
DTXSID101026943
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PRIMARY
RXCUI
1373391
Created by admin on Sat Dec 16 05:03:27 GMT 2023 , Edited by admin on Sat Dec 16 05:03:27 GMT 2023
PRIMARY RxNorm
Display Structure of TECHNETIUM TC-99M TILMANOCEPT