Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H22F3N3 |
| Molecular Weight | 349.3933 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=C(CCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)C=C1
InChI
InChIKey=GAAKALASJNGQKD-UHFFFAOYSA-N
InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2
LY-165163 is a partial agonist of serotonin receptors 5-HT1A and 5-HT1D. It exhibits marked activity at both pre- and postsynaptic dopaminergic D2 (D3 and D1) receptors. LY-165163 caused a significant and dose-dependent hypothermia in rats. As a 5-HT1D receptor agonist, LY-165163 was proposed for the ocular pain treatment.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
| 8.9 null [pKi] | |||
Target ID: CHEMBL217 |
7.2 null [pKi] | ||
Target ID: CHEMBL234 |
7.8 null [pKi] | ||
Target ID: CHEMBL265 |
5.7 null [pKi] | ||
Target ID: P11614 Gene ID: 403963.0 Gene Symbol: HTR1D Target Organism: Canis lupus familiaris (Dog) (Canis familiaris) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
Sample Use Guides
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| Code System | Code | Type | Description | ||
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121930
Created by
admin on Fri Dec 15 18:07:53 GMT 2023 , Edited by admin on Fri Dec 15 18:07:53 GMT 2023
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8HAJ699EWG
Created by
admin on Fri Dec 15 18:07:53 GMT 2023 , Edited by admin on Fri Dec 15 18:07:53 GMT 2023
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1814-64-8
Created by
admin on Fri Dec 15 18:07:53 GMT 2023 , Edited by admin on Fri Dec 15 18:07:53 GMT 2023
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DTXSID30171136
Created by
admin on Fri Dec 15 18:07:53 GMT 2023 , Edited by admin on Fri Dec 15 18:07:53 GMT 2023
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PRIMARY |
ACTIVE MOIETY
