Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H19ClN4.3ClH |
| Molecular Weight | 436.206 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.Cl.ClC1=CC=C(C=C1)N2CCN(CC3=CNC4=C3C=CC=N4)CC2
InChI
InChIKey=KJSOYZLYCFYXFC-UHFFFAOYSA-N
InChI=1S/C18H19ClN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. | 1996 May 10 |
|
| Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats. | 2001 |
|
| Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. | 2001 Apr 12 |
|
| Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. | 2001 Jun 4 |
|
| Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex. | 2002 Nov 1 |
|
| Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors. | 2003 Jun |
|
| Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina. | 2003 Jun |
|
| Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice. | 2003 Jun 16 |
|
| L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-dopamine receptors. | 2003 Mar |
|
| Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in mice. | 2004 Oct |
|
| Regulation of working memory by dopamine D4 receptor in rats. | 2004 Sep |
|
| Dopamine D4 receptors inhibit depolarization-induced [3H]GABA release in the rat subthalamic nucleus. | 2004 Sep 13 |
|
| Tonic modulation of inhibition by dopamine D4 receptors in the rat hippocampus. | 2005 |
|
| 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. | 2005 Jul |
|
| A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. | 2005 Jul |
|
| The combination of nicotine with the D2 antagonist raclopride or the weak D4 antagonist L-745,870 generates a clozapine-like facilitation of NMDA receptor-mediated neurotransmission in pyramidal cells of the rat medial prefrontal cortex. | 2005 Jun |
|
| Involvement of dopamine D3 and D4 receptors in the discriminative stimulus properties of cocaine in the rat. | 2005 Nov |
|
| Control of the subthalamic innervation of the rat globus pallidus by D2/3 and D4 dopamine receptors. | 2006 Dec |
|
| Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum. | 2006 May |
|
| PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain. | 2006 Oct |
|
| Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin. | 2007 Mar |
|
| Dopamine D(4) receptor activation decreases the expression of mu-opioid receptors in the rat striatum. | 2007 May 20 |
|
| A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. | 2008 Jun |
|
| Dopamine D4 receptor antagonist L745,870 abolishes cognitive effects of intracerebroventricular angiotensin IV and des-Phe(6)-Ang IV in rats. | 2009 Feb |
|
| Dopaminergic modulation of risk-based decision making. | 2009 Feb |
|
| p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission. | 2010 Dec 25 |
|
| D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD. | 2010 Jan |
|
| Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: role of dopamine receptor type 4. | 2010 Jul |
|
| Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis. | 2011 Nov |
Patents
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| Code System | Code | Type | Description | ||
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8H9TSV2PSX
Created by
admin on Sat Dec 16 14:53:22 GMT 2023 , Edited by admin on Sat Dec 16 14:53:22 GMT 2023
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866021-03-6
Created by
admin on Sat Dec 16 14:53:22 GMT 2023 , Edited by admin on Sat Dec 16 14:53:22 GMT 2023
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49759035
Created by
admin on Sat Dec 16 14:53:22 GMT 2023 , Edited by admin on Sat Dec 16 14:53:22 GMT 2023
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PRIMARY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
