U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry MIXED
Molecular Formula C23H29NO3.ClH
Molecular Weight 403.942
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 3
E/Z Centers 0
Charge 0
Stereo Comments Assumed mixed

SHOW SMILES / InChI
Structure of FENBUTRAZATE HYDROCHLORIDE

SMILES

Cl.CCC(C(=O)OCCN1CCOC(C1C)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=QYNMGTGFHCYFIE-UHFFFAOYSA-N
InChI=1S/C23H29NO3.ClH/c1-3-21(19-10-6-4-7-11-19)23(25)27-17-15-24-14-16-26-22(18(24)2)20-12-8-5-9-13-20;/h4-13,18,21-22H,3,14-17H2,1-2H3;1H

HIDE SMILES / InChI
Fenbutrazate is a prodrug of phenmetrazine, a psychostimulant for the treatment of obesity. Fenbutrazate acts as an agonist of monoamine transportes upon conversion to the active metabolite. The drug is no longer marketed due to its addictive profile.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Clinical trial of cafilon and ritalin in the treatment of obesity.
1957 Sep
Pharmacophore modeling, virtual screening, and in vitro testing reveal haloperidol, eprazinone, and fenbutrazate as neurokinin receptors ligands.
2014 Jun 23
Patents

Patents

Sample Use Guides

The drug is available in the forn of tablets (20 mg).
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
FENBUTRAZATE HYDROCHLORIDE
MART.   MI   WHO-DD  
Common Name English
Fenbutrazate hydrochloride [WHO-DD]
Common Name English
R-381
Code English
FENBUTRAZATE HYDROCHLORIDE [MI]
Common Name English
2-(3-METHYL-2-PHENYLMORPHOLINO)ETHYL 2-PHENYLBUTYRATE HYDROCHLORIDE
Systematic Name English
PHENBUTRAZATE HYDROCHLORIDE
Common Name English
FENBUTRAZATE HYDROCHLORIDE [MART.]
Common Name English
FENBUTRAZATE HCL
Common Name English
BENZENEACETIC ACID, .ALPHA.-ETHYL-, 2-(3-METHYL-2-PHENYL-4-MORPHOLINYL)ETHYL ESTER, HYDROCHLORIDE (1:1)
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID10983370
Created by admin on Fri Dec 15 17:24:18 GMT 2023 , Edited by admin on Fri Dec 15 17:24:18 GMT 2023
PRIMARY
MERCK INDEX
m1157
Created by admin on Fri Dec 15 17:24:18 GMT 2023 , Edited by admin on Fri Dec 15 17:24:18 GMT 2023
PRIMARY Merck Index
SMS_ID
100000087482
Created by admin on Fri Dec 15 17:24:18 GMT 2023 , Edited by admin on Fri Dec 15 17:24:18 GMT 2023
PRIMARY
EVMPD
SUB02109MIG
Created by admin on Fri Dec 15 17:24:18 GMT 2023 , Edited by admin on Fri Dec 15 17:24:18 GMT 2023
PRIMARY
ECHA (EC/EINECS)
229-330-5
Created by admin on Fri Dec 15 17:24:18 GMT 2023 , Edited by admin on Fri Dec 15 17:24:18 GMT 2023
PRIMARY
FDA UNII
8G5106B4AP
Created by admin on Fri Dec 15 17:24:18 GMT 2023 , Edited by admin on Fri Dec 15 17:24:18 GMT 2023
PRIMARY
PUBCHEM
22982
Created by admin on Fri Dec 15 17:24:18 GMT 2023 , Edited by admin on Fri Dec 15 17:24:18 GMT 2023
PRIMARY
CAS
6474-85-7
Created by admin on Fri Dec 15 17:24:18 GMT 2023 , Edited by admin on Fri Dec 15 17:24:18 GMT 2023
PRIMARY