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Details

Stereochemistry MIXED
Molecular Formula C23H29NO3
Molecular Weight 367.4813
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FENBUTRAZATE

SMILES

CCC(C(=O)OCCN1CCOC(C1C)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=BAQKJENAVQLANS-UHFFFAOYSA-N
InChI=1S/C23H29NO3/c1-3-21(19-10-6-4-7-11-19)23(25)27-17-15-24-14-16-26-22(18(24)2)20-12-8-5-9-13-20/h4-13,18,21-22H,3,14-17H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C23H29NO3
Molecular Weight 367.4813
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Fenbutrazate is a prodrug of phenmetrazine, a psychostimulant for the treatment of obesity. Fenbutrazate acts as an agonist of monoamine transportes upon conversion to the active metabolite. The drug is no longer marketed due to its addictive profile.

CNS Activity

CNS Active
3,913

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
Monoamine transporters; Norepinephrine & dopamine
2
Agonist
2,678

Conditions

ConditionModalityTargetsHighest PhaseProduct
Obesity
203
 Primary
Withdrawn
Unknown

PubMed

Patents

20030087925
6

Sample Use Guides

In Vivo Use Guide
The drug is available in the forn of tablets (20 mg).
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
BKY8H56395
Record Status Validated (UNII)
Record Version
NIH
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