U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C9H14O
Molecular Weight 138.2069
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHORONE

SMILES

CC(C)=CC(=O)C=C(C)C

InChI

InChIKey=MTZWHHIREPJPTG-UHFFFAOYSA-N
InChI=1S/C9H14O/c1-7(2)5-9(10)6-8(3)4/h5-6H,1-4H3

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
Phorone (diisopropylidene acetone), a glutathione depletor, decreases rat glucocorticoid receptor binding in vivo.
1992 Jul
Differential activation of heat-shock and oxidation-specific stress genes in chemically induced oxidative stress.
1995 Jul 15
Induction of CYP2B1 mediated pentoxyresorufin O-dealkylase activity in different species, sex and tissue by prototype 2B1-inducers.
1995 Mar 30
Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) in isolated rat hepatocytes.
2001 Apr
Role of glutathione in metabolic degradation of dichloromethane in rats.
2002 Mar 24
The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress.
2005 Apr 1
Phosphorinanes as ligands for palladium-catalyzed cross-coupling chemistry.
2006 Jan 5
Mitochondrial oxidative stress and permeability transition in isoniazid and rifampicin induced liver injury in mice.
2006 Jul
Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice.
2007
Identification of glutathione depletion-responsive genes using phorone-treated rat liver.
2007 Dec
Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue.
2007 Jan
Decolorization potential of mixed microbial consortia for reactive and disperse textile dyestuffs.
2007 Jun
High hepatic glutathione stores alleviate Fas-induced apoptosis in mice.
2007 May
Comparison of the effects of buthioninesulfoximine and phorone on the metabolism of sulfur-containing amino acids in rat liver.
2008 Apr 18
Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.
2008 Sep
The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts.
2009 Jul 29
Toxicogenomic biomarkers for liver toxicity.
2009 Mar
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.
2009 Mar
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.
2010 Aug 1
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.
2010 Jul
Mechanism-based biomarker gene sets for glutathione depletion-related hepatotoxicity in rats.
2010 Sep 15
Patents

Patents

Name Type Language
PHORONE
MI  
Systematic Name English
2,6-DIMETHYL-2,5-HEPTADIEN-4-ONE
Systematic Name English
DIISOPROPYLIDENE ACETONE
Systematic Name English
NSC-38718
Code English
PHORONE [MI]
Common Name English
DIISOBUTENYL KETONE
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID1021584
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY
WIKIPEDIA
PHORONE
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY
ECHA (EC/EINECS)
207-986-3
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY
CAS
504-20-1
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY
PUBCHEM
10438
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY
FDA UNII
8F20OEI0MV
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY
MERCK INDEX
m8715
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY Merck Index
MESH
C018637
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY
CHEBI
35572
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY
NSC
38718
Created by admin on Sat Dec 16 02:15:50 GMT 2023 , Edited by admin on Sat Dec 16 02:15:50 GMT 2023
PRIMARY