Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H14O |
| Molecular Weight | 138.2069 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)=CC(=O)C=C(C)C
InChI
InChIKey=MTZWHHIREPJPTG-UHFFFAOYSA-N
InChI=1S/C9H14O/c1-7(2)5-9(10)6-8(3)4/h5-6H,1-4H3
| Molecular Formula | C9H14O |
| Molecular Weight | 138.2069 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Phorone (diisopropylidene acetone), a glutathione depletor, decreases rat glucocorticoid receptor binding in vivo. | 1992 Jul |
|
| Differential activation of heat-shock and oxidation-specific stress genes in chemically induced oxidative stress. | 1995 Jul 15 |
|
| Induction of CYP2B1 mediated pentoxyresorufin O-dealkylase activity in different species, sex and tissue by prototype 2B1-inducers. | 1995 Mar 30 |
|
| Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) in isolated rat hepatocytes. | 2001 Apr |
|
| Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice. | 2001 May |
|
| Activation of transcription factors by drugs inducing oxidative stress in rat liver. | 2002 Jan 15 |
|
| Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. | 2002 Jul |
|
| Role of glutathione in metabolic degradation of dichloromethane in rats. | 2002 Mar 24 |
|
| Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress. | 2003 Aug |
|
| Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice. | 2003 Nov |
|
| Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation. | 2004 Apr 23 |
|
| Synthesis of radioiodine labeled dibenzyl disulfide for evaluation of tumor cell uptake. | 2004 Mar 1 |
|
| The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress. | 2005 Apr 1 |
|
| Phosphorinanes as ligands for palladium-catalyzed cross-coupling chemistry. | 2006 Jan 5 |
|
| Mitochondrial oxidative stress and permeability transition in isoniazid and rifampicin induced liver injury in mice. | 2006 Jul |
|
| Serum iron increases with acute induction of hepatic heme oxygenase-1 in mice. | 2007 |
|
| Identification of glutathione depletion-responsive genes using phorone-treated rat liver. | 2007 Dec |
|
| Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue. | 2007 Jan |
|
| Decolorization potential of mixed microbial consortia for reactive and disperse textile dyestuffs. | 2007 Jun |
|
| High hepatic glutathione stores alleviate Fas-induced apoptosis in mice. | 2007 May |
|
| Comparison of the effects of buthioninesulfoximine and phorone on the metabolism of sulfur-containing amino acids in rat liver. | 2008 Apr 18 |
|
| Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats. | 2008 Sep |
|
| The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts. | 2009 Jul 29 |
|
| Toxicogenomic biomarkers for liver toxicity. | 2009 Mar |
|
| Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation. | 2009 Mar |
|
| Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB. | 2010 Aug 1 |
|
| c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. | 2010 Jul |
|
| Mechanism-based biomarker gene sets for glutathione depletion-related hepatotoxicity in rats. | 2010 Sep 15 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 02:15:50 GMT 2023
by
admin
on
Sat Dec 16 02:15:50 GMT 2023
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| Record UNII |
8F20OEI0MV
|
| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID1021584
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PHORONE
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207-986-3
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504-20-1
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10438
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8F20OEI0MV
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m8715
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C018637
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35572
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38718
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