U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C38H51NO4.ClH
Molecular Weight 622.277
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MYROPHINE HYDROCHLORIDE ANHYDROUS

SMILES

Cl.[H][C@@]12OC3=C(OCC4=CC=CC=C4)C=CC5=C3[C@@]16CCN(C)[C@]([H])(C5)[C@]6([H])C=C[C@@H]2OC(=O)CCCCCCCCCCCCC

InChI

InChIKey=OIJOFEMANOKQAR-VRVMWUCTSA-N
InChI=1S/C38H51NO4.ClH/c1-3-4-5-6-7-8-9-10-11-12-16-19-34(40)42-33-23-21-30-31-26-29-20-22-32(41-27-28-17-14-13-15-18-28)36-35(29)38(30,37(33)43-36)24-25-39(31)2;/h13-15,17-18,20-23,30-31,33,37H,3-12,16,19,24-27H2,1-2H3;1H/t30-,31+,33-,37-,38-;/m0./s1

HIDE SMILES / InChI
Myrophine is an opiate analog and long-acting prodrug for morphine with a slow onset of effects. It is weaker than morphine as an analgesic but longer-lasting in effects and was thought to have a more local anesthetic effect than morphine, though with a somewhat greater tendency to cause histamine reactions like itching and rash. In addiction studies conducted in human subjects in the 1950s, myrophine did not substitute for morphine in withdrawal, did not produce notable morphine-like effects, and did not produce addiction or dependence regardless of dose or how it was administered.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents
Name Type Language
MYROPHINE HYDROCHLORIDE ANHYDROUS
Common Name English
MORPHINE, O3-BENZYL ETHER, 6-MYRISTATE, HYDROCHLORIDE
Systematic Name English
MYROPHINE HYDROCHLORIDE
Common Name English
((4R,4AR,7S,7AR,12BS)-3-METHYL-9-PHENYLMETHOXY-2,4,4A,7,7A,13-HEXAHYDRO-1H-4,12-METHANOBENZOFURO(3,2-E)ISOQUINOLIN-7-YL) TETRADECANOATE;HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
FDA UNII
8B8YU8Z3NG
Created by admin on Sat Dec 16 10:14:54 GMT 2023 , Edited by admin on Sat Dec 16 10:14:54 GMT 2023
PRIMARY
CAS
108016-75-7
Created by admin on Sat Dec 16 10:14:54 GMT 2023 , Edited by admin on Sat Dec 16 10:14:54 GMT 2023
PRIMARY
PUBCHEM
46878554
Created by admin on Sat Dec 16 10:14:54 GMT 2023 , Edited by admin on Sat Dec 16 10:14:54 GMT 2023
PRIMARY