U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H17BrN2O5.2Na
Molecular Weight 431.189
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEBROFENIN SODIUM

SMILES

[Na+].[Na+].CC1=CC(C)=C(Br)C(C)=C1NC(=O)CN(CC([O-])=O)CC([O-])=O

InChI

InChIKey=ROCOXIOYJYYJEH-UHFFFAOYSA-L
InChI=1S/C15H19BrN2O5.2Na/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23;;/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23);;/q;2*+1/p-2

HIDE SMILES / InChI

Description

Mebrofenin is a chelating component which, when attached to Technetium TC-99M, forms a diagnostic drug marketed under the name Choletec. Choletec is approved by FDA as a hepatobiliary imaging agent.

Originator

E. R. Squibb and Sons
7

Approval Year

1987
111

Conditions

ConditionModalityTargetsHighest PhaseProduct
Hepatobiliary disease
8
 Diagnostic
Approved
8,429
CHOLETEC

PubMed

Patents

US4418208 A
3

Sample Use Guides

In Vivo Use Guide
The dose range of Technetium Tc 99m Mebrofenin in the average patient (70 kg) is: 74-185 MBq (2-5mCi) for nonjaundiced patient and 111-370 MBq (3-10 mCi) for patients with serum bilirubin level greater than 1.5 mg/dL.
Route of Administration: Intravenous
In Vitro Use Guide
Human hepatocyte suspensions were preincubated in 16×100mm glass vials at 37C for 5min, then 0.1% DMSO or chemical inhibitor was added (1 min before), followed by 5uCi/ mL of Technetium Tc 99m Mebrofenin.
SUBSTANCE RECORD
Structure of MEBROFENIN SODIUM
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966