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Details

Stereochemistry ACHIRAL
Molecular Formula C15H17BrN2O5.2Na
Molecular Weight 431.189
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEBROFENIN SODIUM

SMILES

[Na+].[Na+].CC1=CC(C)=C(Br)C(C)=C1NC(=O)CN(CC([O-])=O)CC([O-])=O

InChI

InChIKey=ROCOXIOYJYYJEH-UHFFFAOYSA-L
InChI=1S/C15H19BrN2O5.2Na/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23;;/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23);;/q;2*+1/p-2

HIDE SMILES / InChI

Description

Mebrofenin is a chelating component which, when attached to Technetium TC-99M, forms a diagnostic drug marketed under the name Choletec. Choletec is approved by FDA as a hepatobiliary imaging agent.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
CHOLETEC

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
The dose range of Technetium Tc 99m Mebrofenin in the average patient (70 kg) is: 74-185 MBq (2-5mCi) for nonjaundiced patient and 111-370 MBq (3-10 mCi) for patients with serum bilirubin level greater than 1.5 mg/dL.
Route of Administration: Intravenous
In Vitro Use Guide
Human hepatocyte suspensions were preincubated in 16×100mm glass vials at 37C for 5min, then 0.1% DMSO or chemical inhibitor was added (1 min before), followed by 5uCi/ mL of Technetium Tc 99m Mebrofenin.