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Details

Stereochemistry ACHIRAL
Molecular Formula C15H17BrN2O5.2Na
Molecular Weight 431.189
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEBROFENIN SODIUM

SMILES

[Na+].[Na+].CC1=CC(C)=C(NC(=O)CN(CC([O-])=O)CC([O-])=O)C(C)=C1Br

InChI

InChIKey=ROCOXIOYJYYJEH-UHFFFAOYSA-L
InChI=1S/C15H19BrN2O5.2Na/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23;;/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23);;/q;2*+1/p-2

HIDE SMILES / InChI
Molecular Formula C15H17BrN2O5
Molecular Weight 385.21
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula Na
Molecular Weight 22.98976928
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including: http://www.accessdata.fda.gov/drugsatfda_docs/label/2005/018124s013lbl.pdf

Mebrofenin is a chelating component which, when attached to Technetium TC-99M, forms a diagnostic drug marketed under the name Choletec. Choletec is approved by FDA as a hepatobiliary imaging agent.

Originator

Approval Year

1987
121
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8583
CHOLETEC

Approved Use

Technetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.

Launch Date

1987
PubMed

PubMed

TitleDatePubMed
The role of IDA scintigraphy in the follow-up of liver disease in patients with cystic fibrosis.
2002-07
Quantification of hepatobiliary function as an integral part of imaging with technetium-99m-mebrofenin in health and disease.
1991-01
Patents

Patents

US4418208 A
3

Sample Use Guides

In Vivo Use Guide
The dose range of Technetium Tc 99m Mebrofenin in the average patient (70 kg) is: 74-185 MBq (2-5mCi) for nonjaundiced patient and 111-370 MBq (3-10 mCi) for patients with serum bilirubin level greater than 1.5 mg/dL.
Route of Administration: Intravenous
In Vitro Use Guide
Human hepatocyte suspensions were preincubated in 16×100mm glass vials at 37C for 5min, then 0.1% DMSO or chemical inhibitor was added (1 min before), followed by 5uCi/ mL of Technetium Tc 99m Mebrofenin.
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:40:26 GMT 2025
Edited
by admin
on Mon Mar 31 22:40:26 GMT 2025
Record UNII
89158O7Q0G
Record Status Validated (UNII)
Record Version
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Name Type Language
N-(3-BROMO-2,4,6- TRIMETHYLACETANILIDE)IMINODIACETIC ACID, DISODIUM SALT
Preferred Name English
MEBROFENIN SODIUM
Common Name English
N-(3-BROMO-2,4,6-TRIMETHYLPHENYLCARBAMOYLMETHYL)IMINODIACETIC ACID, DISODIUM SALT
Systematic Name English
SODIUM N-(3-BROMO-2,4,6- TRIMETHYLACETANILIDE)IMINODIACETATE
Systematic Name English
Code System Code Type Description
SMS_ID
100000134189
Created by admin on Mon Mar 31 22:40:26 GMT 2025 , Edited by admin on Mon Mar 31 22:40:26 GMT 2025
PRIMARY
EVMPD
SUB60071
Created by admin on Mon Mar 31 22:40:26 GMT 2025 , Edited by admin on Mon Mar 31 22:40:26 GMT 2025
PRIMARY
FDA UNII
89158O7Q0G
Created by admin on Mon Mar 31 22:40:26 GMT 2025 , Edited by admin on Mon Mar 31 22:40:26 GMT 2025
PRIMARY
PUBCHEM
91618133
Created by admin on Mon Mar 31 22:40:26 GMT 2025 , Edited by admin on Mon Mar 31 22:40:26 GMT 2025
PRIMARY
NIH
NCATS
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