Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.451 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CC[C@@](C)(C=C)C=C1CC[C@@]3([H])[C@@](C)(CCC[C@]23C)C(O)=O
InChI
InChIKey=MHVJRKBZMUDEEV-APQLOABGSA-N
InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,13,15-16H,1,6-12H2,2-4H3,(H,21,22)/t15-,16+,18+,19+,20+/m0/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Evidence for the mechanisms underlying the effects of pimaradienoic acid isolated from the roots of Viguiera arenaria on rat aorta. | 2004 Jan |
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| Design, synthesis and characterization of podocarpate derivatives as openers of BK channels. | 2008 Oct 1 |
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| Bioactive diterpenes from the aerial parts of Anisochilus harmandii. | 2010 May |
Patents
Sample Use Guides
To measure BK activation whole-cell patch clamp on HEK293, expressing BKalpha, was used. The Ca2 concentration in the pipette solution was fixed at pCa 6.5 using a Ca2-EGTA buffer. Depolarization from -60 to -30 mV induced outward currents in both native HEK and HEKBK1. Application of PiMA in a concentration range of 1 to 10 uM increased outward currents in a dose-dependent fashion in HEKBK1 but did not change in native HEK.
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C008911
Created by
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127-27-5
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m8810
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220338
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88R98Z71NI
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2956
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PIMARIC ACID
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DTXSID80858728
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admin on Sat Dec 16 00:30:35 GMT 2023 , Edited by admin on Sat Dec 16 00:30:35 GMT 2023
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SUBSTANCE RECORD
