Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.451 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CC[C@@](C)(C=C)C=C1CC[C@@]3([H])[C@@](C)(CCC[C@]23C)C(O)=O
InChI
InChIKey=MHVJRKBZMUDEEV-APQLOABGSA-N
InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,13,15-16H,1,6-12H2,2-4H3,(H,21,22)/t15-,16+,18+,19+,20+/m0/s1
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.451 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Reactivity of Trametes laccases with fatty and resin acids. | 2001 Apr |
|
| Antimicrobial diterpenes from the stem bark of Mitrephora celebica. | 2002 Aug |
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| Pimarane diterpene from Viguiera arenaria (Asteraceae) inhibit rat carotid contraction. | 2002 Oct |
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| Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. | 2002 Oct |
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| Dehydroabietic acid derivatives as a novel scaffold for large-conductance calcium-activated K+ channel openers. | 2003 Nov 17 |
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| Evidence for the mechanisms underlying the effects of pimaradienoic acid isolated from the roots of Viguiera arenaria on rat aorta. | 2004 Jan |
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| A UV resonance Raman (UVRR) spectroscopic study on the extractable compounds of Scots pine (Pinus sylvestris) wood. Part I: lipophilic compounds. | 2004 Nov |
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| Pharmacological comparison of the vasorelaxant action displayed by kaurenoic acid and pimaradienoic acid. | 2005 Aug |
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| Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb. | 2005 Jan |
|
| Trypanocidal activity of oleoresin and terpenoids isolated from Pinus oocarpa. | 2005 Sep-Oct |
|
| Chemical composition and antidermatophytic properties of volatile fractions of hexanic extract from leaves of Cupressus lusitanica Mill. from Cameroon. | 2006 Jan 16 |
|
| Human monocytes kill M-CSF-expressing glioma cells by BK channel activation. | 2007 Feb |
|
| Pimaradienoic acid inhibits vascular contraction and induces hypotension in normotensive rats. | 2008 Apr |
|
| Ent-pimara-8(14), 15-dien-19-oic acid isolated from the roots of Aralia cordata inhibits induction of inflammatory mediators by blocking NF-kappaB activation and mitogen-activated protein kinase pathways. | 2008 Dec 28 |
|
| Tape-stripping as a method for measuring dermal exposure to resin acids during wood pellet production. | 2008 Mar |
|
| Design, synthesis and characterization of podocarpate derivatives as openers of BK channels. | 2008 Oct 1 |
|
| Molecular mechanisms of paraptosis induction: implications for a non-genetically modified tumor vaccine. | 2009 |
|
| 1,4a,7-Trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodeca-hydro-phenanthrene-1-carboxylic acid. | 2009 Apr 25 |
|
| Immunotherapy of brain cancers: the past, the present, and future directions. | 2010 |
|
| Bioactive diterpenes from the aerial parts of Anisochilus harmandii. | 2010 May |
|
| Subgroup 4 R2R3-MYBs in conifer trees: gene family expansion and contribution to the isoprenoid- and flavonoid-oriented responses. | 2010 Sep |
Patents
Sample Use Guides
To measure BK activation whole-cell patch clamp on HEK293, expressing BKalpha, was used. The Ca2 concentration in the pipette solution was fixed at pCa 6.5 using a Ca2-EGTA buffer. Depolarization from -60 to -30 mV induced outward currents in both native HEK and HEKBK1. Application of PiMA in a concentration range of 1 to 10 uM increased outward currents in a dose-dependent fashion in HEKBK1 but did not change in native HEK.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 00:30:35 GMT 2023
by
admin
on
Sat Dec 16 00:30:35 GMT 2023
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| Record UNII |
88R98Z71NI
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| Record Status |
Validated (UNII)
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| Record Version |
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C008911
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127-27-5
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m8810
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220338
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88R98Z71NI
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2956
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PIMARIC ACID
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DTXSID80858728
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admin on Sat Dec 16 00:30:35 GMT 2023 , Edited by admin on Sat Dec 16 00:30:35 GMT 2023
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