RUBIDIUM ACETATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3O2.Rb
Molecular Weight	144.5118
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Rb+].CC([O-])=O

InChI

InChIKey=FOGKDYADEBOSPL-UHFFFAOYSA-M

InChI=1S/C2H4O2.Rb/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8926857
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3311597 | https://www.ncbi.nlm.nih.gov/pubmed/26442267

Rubidium chloride is an inorganic compound with the formula RbCl. It appears to be nontoxic and therapeutically effective in several types of depressive disorders. This drug develops his action on dopaminergic stimulation reducing the depressive pattern. Also radioactive rubidium-82 chloride is used as diagnostic agent in positron emission tomography (PET).

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 235 Sources: Placidi, G.F. et al. (2012) Recurrent Mood Disorders, retrieved from: https://books.google.ru/books?id=pIvcBQAAQBAJ	Primary		Approved 8429	RUBINORM Approved Use Depression

PubMed

Title	Date	PubMed
Rubidium chloride ingestion by volunteer subjects: initial experience.	1971	5561654
Effects of rubidium chloride on the course of manic-depressive illness.	1978 May	349155
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.	1999 May	10327022
Inhibition of HIV-1 infection by zinc group metal compounds.	1999 Sep	10517314
Protein kinase C-epsilon modulates mitochondrial function and active Na+ transport after oxidant injury in renal cells.	2004 Feb	14570699

Patents

Sample Use Guides

In Vivo Use Guide

540 mg/day

Route of Administration: Oral

In Vitro Use Guide

Rubidium chloride accelerated cAMP synthesis in rat brain cortex membranes. The effect was dose-dependent and yielded above 2-fold activation of adenylate cyclase. It has been shown that Rb+ influenced directly the catalytic subunit of the enzyme and did not substitute Mg2+ in formation of the metal-ATP complex in this reaction. The stimulatory effect of Rb+ was additive to the activation of adenylate cyclase by the half-maximal (0.3 microM) as well as by the saturating (10 microM) forskolin concentrations, pointing to the fact that these effectors activate different isoforms of the enzyme in rat brain cortex.

Name

Type

Language

RUBIDIUM ACETATE

Systematic Name

English

ACETIC ACID, RUBIDIUM SALT

Systematic Name

English

ACETIC ACID, RUBIDIUM SALT (1:1)

Systematic Name

English

Code System Code Type Description

CAS

563-67-7