Details
Stereochemistry | ACHIRAL |
Molecular Formula | C23H29N3O2S |
Molecular Weight | 411.56 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)C1=CC2=C(SC3=C(C=CC=C3)N2CCCN4CCN(CCO)CC4)C=C1
InChI
InChIKey=WNTYBHLDCKXEOT-UHFFFAOYSA-N
InChI=1S/C23H29N3O2S/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27/h2-3,5-8,17,27H,4,9-16H2,1H3
DescriptionSources: http://www.psyweb.com/drughtm/jsp/acetop.jspCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/17606915 | https://www.ncbi.nlm.nih.gov/pubmed/6147851
Sources: http://www.psyweb.com/drughtm/jsp/acetop.jsp
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/17606915 | https://www.ncbi.nlm.nih.gov/pubmed/6147851
Acetophenazine (Tindal) is an antipsychotic drug of moderate-potency. Used in the treatment of disorganized and psychotic thinking. Acetophenazine (Tindal) is also used to help treat false perceptions (e.g. hallucinations or delusions). Acetophenazine acts as an antagonist of dopaminergic D2 receptors in the brain. Acetophenazine exhibited modest androgen receptor binding and antiandrogen activity.
Originator
Sources: https://www.google.com/patents/US2985654
Curator's Comment: reference retrieved from http://www.drugfuture.com/chemdata/Acetophenazine.html
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1871 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17606915 |
0.8 µM [Ki] | ||
Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6147851 |
17.0 nM [IC50] | ||
Target ID: CHEMBL287 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6147851 |
36.0 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | TINDAL Approved UseAcetophenazine ( Tindal ) is an antipsychotic drug of moderate-potency. Used in the treatment of disorganized and psychotic thinking. Acetophenazine ( Tindal ) is also used to help treat false perceptions (e.g. hallucinations or delusions.) Launch Date-2.75875201E11 |
PubMed
Title | Date | PubMed |
---|---|---|
Influence of acetophenazine (Tindal) upon the attitude of cardiac patients. | 1962 Mar |
|
Acetophenazine in ambulatory schizophrenic adults. | 1962 Sep |
|
Clinical experiences with acetophenazine in the elderly psychotic. | 1963 May |
|
Specific therapeutic actions of acetophenazine, perphenazine, and benzquinamide in newly admitted schizophrenic patients. | 1967 Mar-Apr |
|
Acetophenazine and diazepam in anxious depressions. | 1971 Mar |
|
Spin-label study of phenothiazine interactions with erythrocyte ghost membranes: a possible membrane-mediated antisickling action. | 1978 Oct |
|
Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. | 1984 Sep |
|
Management of the behavioral and psychological symptoms of dementia. | 2007 |
|
Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. | 2007 Jul 17 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.psyweb.com/drughtm/jsp/acetop.jsp
Normal dosage: 20mg to 40mg daily, in healthy young adult.
Start: 20mg daily.
Increases: 20mg as needed.
Maintenance: As low as possible in 24 hours.
Maximum: 60mg in 24 hours.
Route of Administration:
Oral
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C29710
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
||
|
WHO-VATC |
QN05AB07
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
||
|
WHO-ATC |
N05AB07
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
16735
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | RxNorm | ||
|
2751-68-0
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
2401
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
SUB05225MIG
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
59
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
17676
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
CHEMBL1085
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
C100162
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
C81085
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
100000087939
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
ACETOPHENAZINE
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
1026
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
8620H6K4QH
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
m991
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | Merck Index | ||
|
DTXSID2022547
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY | |||
|
DB01063
Created by
admin on Fri Dec 15 14:59:16 UTC 2023 , Edited by admin on Fri Dec 15 14:59:16 UTC 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)