Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H13I3N2O4 |
| Molecular Weight | 641.9667 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I
InChI
InChIKey=OBISGMNJKBVZBT-UHFFFAOYSA-N
InChI=1S/C13H13I3N2O4/c1-4-22-13(21)7-8(14)11(17-5(2)19)10(16)12(9(7)15)18-6(3)20/h4H2,1-3H3,(H,17,19)(H,18,20)
DescriptionSources: http://www.drugbank.ca/drugs/DB00271Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/010040s171lbl.pdf
Sources: http://www.drugbank.ca/drugs/DB00271
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/010040s171lbl.pdf
This compound belongs to the class of organic compounds known as aminobenzoic acids. These are benzoic acids containing an amine group attached to the benzene moiety. A commonly used x-ray contrast medium. Used, alone or in combination, for a wide variety of diagnostic imaging methods, including angiography, urography, cholangiography, computed tomography, hysterosalpingography, and retrograde pyelography. It can be used for imaging the gastrointestinal tract in patients allergic to barium. Radiopaque agents are drugs used to help diagnose certain medical problems. They contain iodine, which blocks x-rays. Depending on how the radiopaque agent is given, it localizes or builds up in certain areas of the body. The resulting high level of iodine allows the x-rays to make a "picture" of the area. The areas of the body in which the radiopaque agent localizes will appear white on the x-ray film. This creates the needed distinction, or contrast, between one organ and other tissues.
CNS Activity
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Diagnostic | Cystografin Approved UseRetrograde cystourethrography Launch Date1955 |
|||
| Diagnostic | Gastrografin Approved UseGastrografin (DIATRIZOIC ACID) is indicated for radiographic examination of segments of the gastrointestinal tract (esophagus, stomach, proximal small intestine, and colon). Launch Date1958 |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
3.6 mg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6706519 |
3.36 mg/kg single, intravenous dose: 3.36 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
HYDROGEN IODIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
7 mg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6706519 |
7.2 mg/kg single, intravenous dose: 7.2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
HYDROGEN IODIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
110 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6706519 |
3.36 mg/kg single, intravenous dose: 3.36 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
HYDROGEN IODIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
102 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6706519 |
7.2 mg/kg single, intravenous dose: 7.2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
HYDROGEN IODIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
PubMed
| Title | Date | PubMed |
|---|---|---|
| An approach to the performance of contrast studies in contrast material-reactive persons. | 1975 Aug |
|
| Spontaneous pneumomediastinum. | 2001 Apr |
|
| Temporary pancreatic duct occlusion by ethibloc: cause of microcirculatory shutdown, acute inflammation, and pancreas necrosis. | 2001 Apr |
|
| Shielding effects of metallic encapsulations and radiographic contrast agents for catheter-based intravascular brachytherapy. | 2001 Apr-Jun |
|
| The use of dilute Calogen as a fat density oral contrast medium in upper abdominal computed tomography, compared with the use of water and positive oral contrast media. | 2001 Aug |
|
| Radiographic contrast media induced nephropathy: experimental observations and the protective effect of calcium channel blockers. | 2001 Dec |
|
| Re: Renal artery embolization with diluted hot contrast medium: an experimental study. | 2001 Dec |
|
| [Nephrotoxicity of X-ray contrast media]. | 2001 Jan-Feb |
|
| [Evaluation of aqueous compartments of the body by integral bioimpedance spectrometry in x-ray surgical interventions in children]. | 2001 Jan-Feb |
|
| Glucose alters the susceptibility of mesangial cells to contrast media. | 2001 Jul |
|
| [Jejunum interposition as replacement of the pars descendens duodeni in extensive tubulovillous adenoma]. | 2001 Jul |
|
| Mixed-type hiatal hernia mimicking pulmonary cystic lesion diagnosed by oral urografin in ED. | 2001 Jul |
|
| Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux. | 2001 Jun |
|
| Harmonic scalpel in laparoscopic colorectal surgery. | 2001 Mar |
|
| BaSO4-loaded agarose: a construction material for multimodality imaging phantoms. | 2001 May |
|
| Changes in intrarenal oxygenation as evaluated by BOLD MRI in a rat kidney model for radiocontrast nephropathy. | 2001 May |
|
| Contrast medium precipitation in the stomach between contiguous plain and contrast CT scans. | 2001 May-Jun |
|
| Retrospective study on the effects of lipiodolization before a potentially curative hepatectomy for colorectal liver metastases: long-term results of a pilot study. | 2001 May-Jun |
|
| Excretory urography by intraosseous injection of contrast media in a rabbit model. | 2001 May-Jun |
|
| [Opportunities of delayed densitometry of "late (fixed) contrast" as a test for tumors in residual mediastinal lesion in primary mediastinal lymphosarcoma after polychemotherapy]. | 2002 |
|
| Ionic radiocontrast media disrupt intercellular contacts via an extracellular calcium-independent mechanism. | 2002 |
|
| Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric Type I diabetes mellitus. | 2002 Apr |
|
| Gastrografin administration in the treatment of postoperative delayed gastric emptying. | 2002 Apr |
|
| Effect of iomeprol on rat hippocampal slice synaptic transmission: comparison with other X-ray contrast agents. | 2002 Apr |
|
| Diagnosis and management of enterovesical fistulas in patients with Crohn's disease. | 2002 Aug |
|
| Thumbprinting due to ischemic colitis in a patient on oral anticoagulation. | 2002 Aug-Sep |
|
| Use of near-infrared reflection spectroscopy to study the effects of X-ray contrast media on renal tolerance in rats: effects of a prostacyclin analogue and of phosphodiesterase inhibitors. | 2002 Dec |
|
| Rectal washout with cytotoxic solution can be extended to the whole colon. | 2002 Dec |
|
| Evidence for involvement of mast cell degranulation and subsequent stimulation of histamine H1 and H2 receptors in radiographic contrast media-increased vascular permeability in rats. | 2002 Dec |
|
| Primary anastomosis and diverting colostomy in diffuse diverticular peritonitis. | 2002 Feb |
|
| Virtual gastroduodenoscopy: a new look at the bypassed stomach and duodenum after laparoscopic Roux-en-Y gastric bypass for morbid obesity. | 2002 Feb |
|
| The utility of contrast studies and drains in the management of patients after Roux-en-Y gastric bypass. | 2002 Feb |
|
| Systemic platelet effects of contrast media: implications for cardiologic research and clinical practice. | 2002 Jan |
|
| Effects of intrathecal injection of diatrizoate on dopamine receptors. | 2002 Jul |
|
| Local tissue toxicity in response to extravascular extravasation of magnetic resonance contrast media. | 2002 Jul |
|
| Aneurysmal bone cysts: treatment with direct percutaneous Ethibloc injection: long-term results. | 2002 Jul-Aug |
|
| Type IV diaphragmatic hiatal hernia. | 2002 Jun-Jul |
|
| Early esophageal transit study after laparoscopic fundoplication: how useful is it? | 2002 Mar |
|
| Gastrocolocutaneous Fistula as a complication of peg tube placement. | 2002 Mar |
|
| Changes in the fibrinolytic system during angiography with ionic and with nonionic contrast media. | 2002 Mar |
|
| Laparoscopic repair for perforated peptic ulcer: a randomized controlled trial. | 2002 Mar |
|
| [Ultrasound and X-ray urethrography and urethroscopy during endoscopic operations on the urethra]. | 2002 Mar-Apr |
|
| A case of gastric duplication evaluated by gastric emptying scintigraphy. | 2002 May |
|
| New strategies in nonoperative management of meconium ileus. | 2002 May |
|
| The role of theophylline in contrast-induced nephropathy: a case-control study. | 2002 Nov |
|
| The value of contrast radiology for postoperative adhesive small bowel obstruction. | 2002 Nov-Dec |
|
| Chronic renal dysfunction late after liver transplantation. | 2002 Oct |
|
| Renal chemoembolization with mitomycin c/Ethibloc: pharmacokinetics and efficacy in an animal model. | 2002 Sep |
|
| Iothalamate measured by capillary electrophoresis is a suitable alternative to radiolabeled inulin in renal micropuncture. | 2002 Sep |
|
| [Fast method of labelling leukocytes with 99mTc HM PAO]. | 2002 Sep-Oct |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: For radiographic examination of segments of the gastrointestinal tract (Gastrografin) oral administration: adult oral dosage may range from 30 to 90 mL (11 to 33 g iodine), depending on the nature of the examination and the size of the patient. For Enemas or Enterostomy Instillations: should be diluted when it is used for enemas and enterostomy instillations. When used as an enema, the suggested dilution for adults is 240 mL (88 g iodine) in 1,000 mL of tap water. http://www.drugs.com/pro/gastrografin.html
;
The dose for retrograde use in cystography and voiding cystourethrography ranges from 25 to 300 mL depending on the age of the patient and the degree of bladder irritability
Route of Administration:
Other
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID70176069
Created by
admin on Fri Dec 15 15:34:45 GMT 2023 , Edited by admin on Fri Dec 15 15:34:45 GMT 2023
|
PRIMARY | |||
|
16567
Created by
admin on Fri Dec 15 15:34:45 GMT 2023 , Edited by admin on Fri Dec 15 15:34:45 GMT 2023
|
PRIMARY | |||
|
2168-75-4
Created by
admin on Fri Dec 15 15:34:45 GMT 2023 , Edited by admin on Fri Dec 15 15:34:45 GMT 2023
|
PRIMARY | |||
|
85KD8I5N2U
Created by
admin on Fri Dec 15 15:34:45 GMT 2023 , Edited by admin on Fri Dec 15 15:34:45 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
