U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C13H13I3N2O4
Molecular Weight 641.9667
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIATRIZOATE ETHYL

SMILES

CCOC(=O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I

InChI

InChIKey=OBISGMNJKBVZBT-UHFFFAOYSA-N
InChI=1S/C13H13I3N2O4/c1-4-22-13(21)7-8(14)11(17-5(2)19)10(16)12(9(7)15)18-6(3)20/h4H2,1-3H3,(H,17,19)(H,18,20)

HIDE SMILES / InChI

Molecular Formula C13H13I3N2O4
Molecular Weight 641.9667
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/010040s171lbl.pdf

This compound belongs to the class of organic compounds known as aminobenzoic acids. These are benzoic acids containing an amine group attached to the benzene moiety. A commonly used x-ray contrast medium. Used, alone or in combination, for a wide variety of diagnostic imaging methods, including angiography, urography, cholangiography, computed tomography, hysterosalpingography, and retrograde pyelography. It can be used for imaging the gastrointestinal tract in patients allergic to barium. Radiopaque agents are drugs used to help diagnose certain medical problems. They contain iodine, which blocks x-rays. Depending on how the radiopaque agent is given, it localizes or builds up in certain areas of the body. The resulting high level of iodine allows the x-rays to make a "picture" of the area. The areas of the body in which the radiopaque agent localizes will appear white on the x-ray film. This creates the needed distinction, or contrast, between one organ and other tissues.

Originator

Curator's Comment: Diatrizoic acid was discovered in 1953 simultaneously and independently by Schering AG in Berlin and by Sterling-Winthrop in the USA.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Cystografin

Approved Use

Retrograde cystourethrography

Launch Date

1955
Diagnostic
Gastrografin

Approved Use

Gastrografin (DIATRIZOIC ACID) is indicated for radiographic examination of segments of the gastrointestinal tract (esophagus, stomach, proximal small intestine, and colon).

Launch Date

1958
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
3.6 mg/mL
3.36 mg/kg single, intravenous
dose: 3.36 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
HYDROGEN IODIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
7 mg/mL
7.2 mg/kg single, intravenous
dose: 7.2 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
HYDROGEN IODIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
110 min
3.36 mg/kg single, intravenous
dose: 3.36 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
HYDROGEN IODIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
102 min
7.2 mg/kg single, intravenous
dose: 7.2 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
HYDROGEN IODIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Transcervical catheterization and cervical patency during the oestrous cycle in domestic cats.
2001
The accordion sign at CT: report of a case of Crohn's disease with diffuse colonic involvement.
2001
An analysis of mechanisms underlying the antifibrinolytic properties of radiographic contrast agents.
2001 Dec
Preoperative bowel preparation with meglumine and sodium diatrizoate (Gastrografin): a prospective randomised comparison.
2001 Dec
Flow-directed microcatheters for cerebral embolizations using Ethibloc--an in vitro study.
2001 Dec
Radiographic contrast media induced nephropathy: experimental observations and the protective effect of calcium channel blockers.
2001 Dec
Re: Renal artery embolization with diluted hot contrast medium: an experimental study.
2001 Dec
Diagnostic accuracy of focused appendiceal CT in clinically equivocal cases of acute appendicitis.
2001 Dec
Glucose alters the susceptibility of mesangial cells to contrast media.
2001 Jul
[Jejunum interposition as replacement of the pars descendens duodeni in extensive tubulovillous adenoma].
2001 Jul
Mixed-type hiatal hernia mimicking pulmonary cystic lesion diagnosed by oral urografin in ED.
2001 Jul
Add-on angiotensin receptor blockade with maximized ACE inhibition.
2001 Jun
CT colonography without cathartic preparation: feasibility study.
2001 Jun
Effects in vivo of iohexol and diatrizoate on human plasma acetyl- and butyryl-cholinesterase activity.
2001 Mar
Contrast medium precipitation in the stomach between contiguous plain and contrast CT scans.
2001 May-Jun
Rapid diagnosis of sigmoid volvulus with water soluble urografin in emergency service.
2001 Nov
Videourodynamic and sphincter motor unit potential analyses in Parkinson's disease and multiple system atrophy.
2001 Nov
Differential effects of radiocontrast agents on human umbilical vein endothelial cells: cytotoxicity and modulators of thrombogenicity.
2001 Nov 20
Effect of ionic and nonionic contrast media on fibrinolysis in patients undergoing angiocardiography.
2001 Oct
Oesophageal rupture resulting from airbag deployment during a motor vehicle accident.
2001 Sep
Ionic radiocontrast media disrupt intercellular contacts via an extracellular calcium-independent mechanism.
2002
[Which imaging in case of sigmoid diverticulitis? The value of ultrasound (Conventional B-mode in combination with hydrocolonsonography and colour flow Doppler) in comparison to the well-established modalities like contrast enema and helical computertomography].
2002 Apr
Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric Type I diabetes mellitus.
2002 Apr
Gastrografin administration in the treatment of postoperative delayed gastric emptying.
2002 Apr
Effect of iomeprol on rat hippocampal slice synaptic transmission: comparison with other X-ray contrast agents.
2002 Apr
Diagnosis and management of enterovesical fistulas in patients with Crohn's disease.
2002 Aug
Electrocardiographic effects of diagnostic imaging agents.
2002 Aug
Use of near-infrared reflection spectroscopy to study the effects of X-ray contrast media on renal tolerance in rats: effects of a prostacyclin analogue and of phosphodiesterase inhibitors.
2002 Dec
Evidence for involvement of mast cell degranulation and subsequent stimulation of histamine H1 and H2 receptors in radiographic contrast media-increased vascular permeability in rats.
2002 Dec
Primary anastomosis and diverting colostomy in diffuse diverticular peritonitis.
2002 Feb
Systemic platelet effects of contrast media: implications for cardiologic research and clinical practice.
2002 Jan
Plasma exogenous creatinine clearance test in dogs: comparison with other methods and proposed limited sampling strategy.
2002 Jan-Feb
Assessment of hypothalamic-pituitary-adrenal axis function after corticosteroid therapy in inflammatory bowel disease.
2002 Jul
Local tissue toxicity in response to extravascular extravasation of magnetic resonance contrast media.
2002 Jul
Aneurysmal bone cysts: treatment with direct percutaneous Ethibloc injection: long-term results.
2002 Jul-Aug
Early esophageal transit study after laparoscopic fundoplication: how useful is it?
2002 Mar
Gastrocolocutaneous Fistula as a complication of peg tube placement.
2002 Mar
Laparoscopic repair for perforated peptic ulcer: a randomized controlled trial.
2002 Mar
Role of NO in endothelin-regulated drug transport in the renal proximal tubule.
2002 Mar
Long-term survival of patients with stage IV hypopharyngeal cancer: impact of fundus rotation gastroplasty.
2002 May
New strategies in nonoperative management of meconium ileus.
2002 May
Renal excretion of ingested gastrografin: clinical relevance in early postoperative treatment of patients who have undergone gastric surgery.
2002 May
Jejunum free flap in hypopharynx reconstruction: case series.
2002 May 10
Safety and efficacy of postoperative continuous positive airway pressure to prevent pulmonary complications after Roux-en-Y gastric bypass.
2002 May-Jun
The role of theophylline in contrast-induced nephropathy: a case-control study.
2002 Nov
Pressure-assisted micturating cystourethrography: reduction in duration of procedure and fluoroscopy time.
2002 Nov
The value of contrast radiology for postoperative adhesive small bowel obstruction.
2002 Nov-Dec
Venous port salvage utilizing low dose tPA.
2002 Nov-Dec
The diagnostic yield of colonoscopy and the therapeutic value of intraduodenal amidotrizoic acid injection in intestinal Diphyllobothrium latum infection: report of a case.
2002 Sep
Iothalamate measured by capillary electrophoresis is a suitable alternative to radiolabeled inulin in renal micropuncture.
2002 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: For radiographic examination of segments of the gastrointestinal tract (Gastrografin) oral administration: adult oral dosage may range from 30 to 90 mL (11 to 33 g iodine), depending on the nature of the examination and the size of the patient. For Enemas or Enterostomy Instillations: should be diluted when it is used for enemas and enterostomy instillations. When used as an enema, the suggested dilution for adults is 240 mL (88 g iodine) in 1,000 mL of tap water. http://www.drugs.com/pro/gastrografin.html ;
The dose for retrograde use in cystography and voiding cystourethrography ranges from 25 to 300 mL depending on the age of the patient and the degree of bladder irritability
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:34:45 GMT 2023
Edited
by admin
on Fri Dec 15 15:34:45 GMT 2023
Record UNII
85KD8I5N2U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIATRIZOATE ETHYL
Common Name English
ETHYL DIATRIZOATE
Common Name English
ETHYL 3,5-BIS(ACETYLAMINO)-2,4,6-TRIIODOBENZOATE
Systematic Name English
WIN-8883
Code English
DIATRIZOIC ACID, ETHYL ESTER
Common Name English
3,5-DIACETAMIDO-2,4,6-TRIIODO-BENZOIC ACID ETHYL ESTER
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID70176069
Created by admin on Fri Dec 15 15:34:45 GMT 2023 , Edited by admin on Fri Dec 15 15:34:45 GMT 2023
PRIMARY
PUBCHEM
16567
Created by admin on Fri Dec 15 15:34:45 GMT 2023 , Edited by admin on Fri Dec 15 15:34:45 GMT 2023
PRIMARY
CAS
2168-75-4
Created by admin on Fri Dec 15 15:34:45 GMT 2023 , Edited by admin on Fri Dec 15 15:34:45 GMT 2023
PRIMARY
FDA UNII
85KD8I5N2U
Created by admin on Fri Dec 15 15:34:45 GMT 2023 , Edited by admin on Fri Dec 15 15:34:45 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY