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Details

Stereochemistry ACHIRAL
Molecular Formula CO3.Al.Na.2HO
Molecular Weight 143.9949
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIHYDROXYALUMINUM SODIUM CARBONATE

SMILES

C(=O)([O-])[O-].[Al+3].[Na+].[OH-].[OH-]

InChI

InChIKey=SEIGJEJVIMIXIU-UHFFFAOYSA-J
InChI=1S/CH2O3.Al.Na.2H2O/c2-1(3)4;;;;/h(H2,2,3,4);;;2*1H2/q;+3;+1;;/p-4

HIDE SMILES / InChI
Potash (Dihydroxyaluminum Sodium Carbonate), a component of Kompensan-S Forte in Germany, is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Kompensan-S Forte is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.

Originator

Curator's Comment:: # Pfizer

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Kompensan

Approved Use

Gastrointestinal disorders: Dyspepsia, Duodenal Ulcer, Erosive Esophagitis, Gastric Ulcer, Gastroesophageal Reflux Disease, Zollinger-Ellison Syndrome, Hyperphosphatemia
PubMed

PubMed

TitleDatePubMed
Automation of dihydroxyaluminum sodium carbonate analysis in antacid tablets by energy dispersive X-ray fluorescence.
1990 May-Jun
Patents

Sample Use Guides

Usual Adult Dose for Dyspepsia: 500 to 600 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Duodenal Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Erosive Esophagitis: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Gastric Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Gastroesophageal Reflux Disease: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Zollinger-Ellison Syndrome: 500 to 3600 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Hyperphosphatemia: 500 to 1000 mg orally 4 times a day, with meals and at bedtime. The dosage should be titrated to the serum phosphate level.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
DIHYDROXYALUMINUM SODIUM CARBONATE
II   MART.   MI   USP   VANDF   WHO-DD  
Systematic Name English
SODIUM (T-4)-(CARBONATO(2-)-O,O')DIHYDROXYALUMINATE(1-)
Common Name English
DIHYDROXYALUMINUM SODIUM CARBONATE [USP]
Common Name English
ALUMINUM, (CARBONATO(1-)-O)DIHYDROXY-, MONOSODIUM SALT
Common Name English
ALUMINATE(1-), (CARBONATO(2-)-.KAPPA.O,.KAPPA.O')DIHYDROXY-, SODIUM (1:1), (T-4)-
Systematic Name English
ALUMINATE(1-), (CARBONATO)DIHYDROXY-, SODIUM
Common Name English
SODIUM (CARBONATO)DIHYDROXYALUMINATE(1-)
Common Name English
DASC
Common Name English
ALUMINATE(1-), (CARBONATO(2-)-.KAPPA.O)DIHYDROXY-, SODIUM
Common Name English
DIHYDROXYALUMINUM SODIUM CARBONATE [II]
Common Name English
DIHYDROXYALUMINUM SODIUM CARBONATE [MART.]
Common Name English
DIHYDROXYALUMINUM SODIUM CARBONATE [MI]
Common Name English
ROLAIDS (PRE-1995)
Brand Name English
DIHYDROXYALUMINUM SODIUM CARBONATE [WHO-DD]
Common Name English
CARBALDRATE ANHYDROUS
Common Name English
ALUMINIUM, (CARBONATO(1-)-O)DIHYDROXY-, MONOSODIUM SALT
Common Name English
DIHYDROXYALUMINIUM SODIUM CARBONATE
Systematic Name English
DIHYDROXYALUMINUM SODIUM CARBONATE [VANDF]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 331.11
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
NCI_THESAURUS C29701
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
CFR 21 CFR 331.15
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
Code System Code Type Description
RXCUI
23163
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C76484
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY
ECHA (EC/EINECS)
240-536-4
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY
MESH
C016386
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY
CAS
539-68-4
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
SUPERSEDED
MERCK INDEX
M4472
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY Merck Index
EVMPD
SUB13596MIG
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY
CAS
12011-77-7
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
ALTERNATIVE
FDA UNII
84H8Z9550J
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY
CAS
16482-55-6
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY
PUBCHEM
9793815
Created by admin on Fri Jun 25 20:43:31 UTC 2021 , Edited by admin on Fri Jun 25 20:43:31 UTC 2021
PRIMARY