Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H14ClN3O6 |
Molecular Weight | 367.741 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)OCC(=O)NC1=CC(=CC(NC(=O)COC(C)=O)=C1Cl)C#N
InChI
InChIKey=VNVBCWREJHKWSG-UHFFFAOYSA-N
InChI=1S/C15H14ClN3O6/c1-8(20)24-6-13(22)18-11-3-10(5-17)4-12(15(11)16)19-14(23)7-25-9(2)21/h3-4H,6-7H2,1-2H3,(H,18,22)(H,19,23)
DescriptionSources: http://www.chemdrug.com/article/8/3285/16420469.html
Sources: http://www.chemdrug.com/article/8/3285/16420469.html
Acreozast is an orally active antiallergic agent, which has anti-inflammatory activity. It was undergoing phase II clinical trials in Japan for the following condition: Asthma and Atopic dermatitis. Toyobo discontinued the development of acreozast in 1996.
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/9068982
rats: 3-30 mg/kg
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/7683300
Histamine release was enhanced by the pretreatment of basophils with recombinant interleukin 3 (rIL-3) (0.3-10 U/ml) in 18 out of 22 subjects. Histamine release in the presence of rIL-3 was inhibited by TYB-2285 (ACREOZAST) in a dose-dependent manner (1-100 microM). Histamine release in the absence of rIL-3 was not inhibited by TYB-2285 at concentrations less than 1 mM.
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C29712
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ACTIVE MOIETY