Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H22N4O.2ClH |
Molecular Weight | 371.305 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3
InChI
InChIKey=GNUCGROXDZMCJI-UHFFFAOYSA-N
InChI=1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H
Minaprine, a psychotropic drug, which was effective in the treatment of various depressive states. This drug was withdrawn because of the serious side effect. It was found, that minaprine inhibited the following enzymes, acetylcholinesterase and monoamine oxidase (MOA) A. It also binds to dopamine D1 and D2 receptors. Experiments on rodents also have revealed that minaprine suppressed the inhibitory effect of hydroxytryptamine (5-HT) on dopamine (DA) release via the inhibition of 5-HT binding at the 5-HT2 receptor on the nerve terminal.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL3199 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10052979 |
85.0 µM [IC50] | ||
Target ID: CHEMBL216 |
17.0 µM [Ki] | ||
Target ID: CHEMBL3358 |
1.0 mM [IC50] | ||
Target ID: CHEMBL2111341 |
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Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8904622
minaprine 100 mg, 200 mg or 300 mg day-1 . The drug was administered for 6 weeks
Route of Administration:
Oral
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C265
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m7551
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ACTIVE MOIETY
SUBSTANCE RECORD