MINAPRINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H22N4O.2ClH
Molecular Weight	371.305
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3

InChI

InChIKey=GNUCGROXDZMCJI-UHFFFAOYSA-N

InChI=1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H22N4O
Molecular Weight	298.3828
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3836113 | https://www.ncbi.nlm.nih.gov/pubmed/7862862 | https://www.ncbi.nlm.nih.gov/pubmed/3954800 | https://www.ncbi.nlm.nih.gov/pubmed/2975224

Minaprine, a psychotropic drug, which was effective in the treatment of various depressive states. This drug was withdrawn because of the serious side effect. It was found, that minaprine inhibited the following enzymes, acetylcholinesterase and monoamine oxidase (MOA) A. It also binds to dopamine D1 and D2 receptors. Experiments on rodents also have revealed that minaprine suppressed the inhibitory effect of hydroxytryptamine (5-HT) on dopamine (DA) release via the inhibition of 5-HT binding at the 5-HT2 receptor on the nerve terminal.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Acetylcholinesterase 207 Target ID: CHEMBL3199 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10052979	Inhibitor 8297	85.0 µM [IC50]
Muscarinic acetylcholine receptor M1 169 Target ID: CHEMBL216 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14998318\|https://www.drugbank.ca/drugs/DB00805	Agonist 2678	17.0 µM [Ki]
Monoamine oxidase A 49 Target ID: CHEMBL3358 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2531423\|https://www.ncbi.nlm.nih.gov/pubmed/3954800	Inhibitor 8297	1.0 mM [IC50]
Dopamine D1 and D2 receptor 2 Target ID: CHEMBL2111341 Sources: https://www.drugbank.ca/drugs/DB00805\|https://www.ncbi.nlm.nih.gov/pubmed/7862862\|https://www.ncbi.nlm.nih.gov/pubmed/3836113	Agonist 2678
Serotonin 2 (5-HT2) receptor 87 Target ID: CHEMBL2093870 Sources: https://www.drugbank.ca/drugs/DB00805\|https://www.ncbi.nlm.nih.gov/pubmed/2530096\|https://www.ncbi.nlm.nih.gov/pubmed/2975224\|https://www.ncbi.nlm.nih.gov/pubmed/3419543	Antagonist 2778

PubMed

Title	Date	PubMed
Pharmacological evaluation of minaprine dihydrochloride, a new psychotropic drug.	1982	6890359
Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database.	2009 Nov	19661215

Sample Use Guides

In Vivo Use Guide

minaprine 100 mg, 200 mg or 300 mg day-1 . The drug was administered for 6 weeks

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:48:07 UTC 2023` Edited by `admin` on `Fri Dec 15 15:48:07 UTC 2023`
Record UNII	82Y7NT6DFT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MINAPRINE HYDROCHLORIDE

Official Name

English

MINAPRINE DIHYDROCHLORIDE [MI]

Common Name

English

MINAPRINE HCL

Common Name

English

4-MORPHOLINEETHANAMINE, N-(4-METHYL-6-PHENYL-3-PYRIDAZINYL)-, DIHYDROCHLORIDE (2) 4-(2-((4-METHYL-6-PHENYL-3-PYRIDAZINYL)AMINO)ETHYL)MORPHOLINE DIHYDROCHLORIDE.

Systematic Name

English

MINAPRINE HYDROCHLORIDE [MART.]

Common Name

English

MINAPRINE HYDROCHLORIDE [JAN]

Common Name

English

Minaprine dihydrochloride [WHO-DD]

Common Name

English

NSC-305742

Code

English

30038CB

Code

English

MINAPRINE DIHYDROCHLORIDE

Common Name

English

30038-CB

Code

English

MINAPRINE HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265