Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H27FN4O2 |
| Molecular Weight | 434.5059 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=CC=C1N2CCN(CCN(C(=O)C3=CC=C(F)C=C3)C4=NC=CC=C4)CC2
InChI
InChIKey=YJZYDPRMWYWYCG-UHFFFAOYSA-N
InChI=1S/C25H27FN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3
4-FLUORO-N-{2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL}-N-(2-PYRIDINYL)BENZAMIDE HYDROCHLORIDE (p-MPPF) is a potent and selective 5-HT1A receptor antagonist. Animal experiments and clinical trials have shown that radiolabeled [(18)F]p-MPPF can be used for 5-hydroxytryptamine(1A) (5-HT(1A)) receptor imaging.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL273 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8182697 |
3.3 nM [Ki] |
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
6603915
Created by
admin on Mon Mar 31 23:22:29 GMT 2025 , Edited by admin on Mon Mar 31 23:22:29 GMT 2025
|
PRIMARY | |||
|
81KHI46E5L
Created by
admin on Mon Mar 31 23:22:29 GMT 2025 , Edited by admin on Mon Mar 31 23:22:29 GMT 2025
|
PRIMARY | |||
|
155204-26-5
Created by
admin on Mon Mar 31 23:22:29 GMT 2025 , Edited by admin on Mon Mar 31 23:22:29 GMT 2025
|
PRIMARY | |||
|
300000045919
Created by
admin on Mon Mar 31 23:22:29 GMT 2025 , Edited by admin on Mon Mar 31 23:22:29 GMT 2025
|
PRIMARY | |||
|
DTXSID20424966
Created by
admin on Mon Mar 31 23:22:29 GMT 2025 , Edited by admin on Mon Mar 31 23:22:29 GMT 2025
|
PRIMARY |