4-FLUORO-N-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-N-2-PYRIDINYLBENZAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H27FN4O2
Molecular Weight	434.5059
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 4-FLUORO-N-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-N-2-PYRIDINYLBENZAMIDE

Structure Search

SMILES

COC1=CC=CC=C1N2CCN(CCN(C(=O)C3=CC=C(F)C=C3)C4=NC=CC=C4)CC2

InChI

InChIKey=YJZYDPRMWYWYCG-UHFFFAOYSA-N

InChI=1S/C25H27FN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3

HIDE SMILES / InChI

Molecular Formula	C25H27FN4O2
Molecular Weight	434.5059
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8855520 | https://www.ncbi.nlm.nih.gov/pubmed/10962253

4-FLUORO-N-{2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL}-N-(2-PYRIDINYL)BENZAMIDE HYDROCHLORIDE (p-MPPF) is a potent and selective 5-HT1A receptor antagonist. Animal experiments and clinical trials have shown that radiolabeled [(18)F]p-MPPF can be used for 5-hydroxytryptamine(1A) (5-HT(1A)) receptor imaging.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 1a (5-HT1a) receptor 172 Target ID: CHEMBL273 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8182697	Antagonist 2778		3.3 nM [Ki]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:38:35 GMT 2023` Edited by `admin` on `Sat Dec 16 10:38:35 GMT 2023`
Record UNII	81KHI46E5L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

4-FLUORO-N-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-N-2-PYRIDINYLBENZAMIDE

Systematic Name

English

P-MPPF

Common Name

English

MPPF

Common Name

English

J621.990J

Code

English

BENZAMIDE, 4-FLUORO-N-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-N-2-PYRIDINYL-

Systematic Name

English

N-(2-PYRIDINYL)-N-(2-(4-(2-METHOXYPHENYL)PIPERAZIN-1-YL)ETHYL)-4-FLUOROBENZAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

6603915