Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C15H20O7 |
Molecular Weight | 312.3151 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](OC\C=C\C2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=CNNXMGXBAZQZDE-HHMSBIESSA-N
InChI=1S/C15H20O7/c16-8-11-12(18)13(19)14(20)15(22-11)21-7-1-2-9-3-5-10(17)6-4-9/h1-6,11-20H,7-8H2/b2-1+/t11-,12-,13+,14-,15-/m1/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/12673010
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12673010
Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Sachaliside 1 was isolated from Rhodiola rosea L. It was discovered the inhibitory effects of Sachaliside 1 on tumor necrosis factor (TNF)-alpha production in the peritoneal macrophages of mice stimulated with lipopolysaccharide (LPS).
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0032640 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17992993 |
Conditions
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Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17992993
The inhibitory effects of the isolated compounds on tumor necrosis factor (TNF)-alpha production in the peritoneal macrophages of mice stimulated with lipopolysaccharide (LPS) were assayed in vitro by microplate colorimetric method. The inhibitory effect of compound 8 (sachaliside 1) was 82.7% against the TNF-alpha production in the peritoneal macrophages of mice stimulated with LPS at a concentration of 10(-5) mol L(-1) in vitro.
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14048613
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7WNF6LR591
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admin on Sat Dec 16 09:54:24 GMT 2023 , Edited by admin on Sat Dec 16 09:54:24 GMT 2023
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132294-76-9
Created by
admin on Sat Dec 16 09:54:24 GMT 2023 , Edited by admin on Sat Dec 16 09:54:24 GMT 2023
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SUBSTANCE RECORD