Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H20O7 |
| Molecular Weight | 312.3151 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](OC\C=C\C2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=CNNXMGXBAZQZDE-HHMSBIESSA-N
InChI=1S/C15H20O7/c16-8-11-12(18)13(19)14(20)15(22-11)21-7-1-2-9-3-5-10(17)6-4-9/h1-6,11-20H,7-8H2/b2-1+/t11-,12-,13+,14-,15-/m1/s1
| Molecular Formula | C15H20O7 |
| Molecular Weight | 312.3151 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Sachaliside 1 was isolated from Rhodiola rosea L. It was discovered the inhibitory effects of Sachaliside 1 on tumor necrosis factor (TNF)-alpha production in the peritoneal macrophages of mice stimulated with lipopolysaccharide (LPS).
Originator
Approval Year
Sample Use Guides
The inhibitory effects of the isolated compounds on tumor necrosis factor (TNF)-alpha production in the peritoneal macrophages of mice stimulated with lipopolysaccharide (LPS) were assayed in vitro by microplate colorimetric method. The inhibitory effect of compound 8 (sachaliside 1) was 82.7% against the TNF-alpha production in the peritoneal macrophages of mice stimulated with LPS at a concentration of 10(-5) mol L(-1) in vitro.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:54:24 GMT 2023
by
admin
on
Sat Dec 16 09:54:24 GMT 2023
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| Record UNII |
7WNF6LR591
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| Record Status |
Validated (UNII)
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| Record Version |
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14048613
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7WNF6LR591
Created by
admin on Sat Dec 16 09:54:24 GMT 2023 , Edited by admin on Sat Dec 16 09:54:24 GMT 2023
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132294-76-9
Created by
admin on Sat Dec 16 09:54:24 GMT 2023 , Edited by admin on Sat Dec 16 09:54:24 GMT 2023
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PRIMARY |