Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H19F3N2O4S |
| Molecular Weight | 452.447 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=CC=C1OC2=CC=C(C=C2)N(CC3=CC=CN=C3)S(=O)(=O)CC(F)(F)F
InChI
InChIKey=ALMACYDZFBMGOR-UHFFFAOYSA-N
InChI=1S/C21H19F3N2O4S/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24/h2-13H,14-15H2,1H3
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14500736 | https://www.ncbi.nlm.nih.gov/pubmed/16123306
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14500736 | https://www.ncbi.nlm.nih.gov/pubmed/16123306
N-(4-(2-Methoxyphenoxy)-phenyl-N-(2,2,2-trifluoroethylsulfonyl)-pyrid-3-ylmethylamine (LY487379) is a selective positive allosteric modulator at metabotropic glutamate subtype 2 receptors (mGluR2). The compound exerts antipsychotic and anxiolytic actions.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage. | 2015-10-24 |
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| On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice. | 2012-01 |
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| Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus. | 2011-03 |
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| Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. | 2010-12 |
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| The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801. | 2010-08-10 |
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| Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment. | 2007-07 |
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| A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. | 2007-07 |
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| A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity. | 2005-12 |
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| Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. | 2005 |
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| Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. | 2003-10 |
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| Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine. | 2003-07-17 |
Patents
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DTXSID10431366
Created by
admin on Wed Apr 02 13:17:47 GMT 2025 , Edited by admin on Wed Apr 02 13:17:47 GMT 2025
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LY-487,379
Created by
admin on Wed Apr 02 13:17:47 GMT 2025 , Edited by admin on Wed Apr 02 13:17:47 GMT 2025
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7WF5ZLL4D9
Created by
admin on Wed Apr 02 13:17:47 GMT 2025 , Edited by admin on Wed Apr 02 13:17:47 GMT 2025
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353231-17-1
Created by
admin on Wed Apr 02 13:17:47 GMT 2025 , Edited by admin on Wed Apr 02 13:17:47 GMT 2025
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9825084
Created by
admin on Wed Apr 02 13:17:47 GMT 2025 , Edited by admin on Wed Apr 02 13:17:47 GMT 2025
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
