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Details

Stereochemistry ACHIRAL
Molecular Formula CO3
Molecular Weight 60.0089
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of CARBONATE ION

SMILES

[O-]C([O-])=O

InChI

InChIKey=BVKZGUZCCUSVTD-UHFFFAOYSA-L
InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2

HIDE SMILES / InChI
Potash (Dihydroxyaluminum Sodium Carbonate), a component of Kompensan-S Forte in Germany, is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Kompensan-S Forte is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.

Originator

Curator's Comment: # Pfizer

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Kompensan

Approved Use

Gastrointestinal disorders: Dyspepsia, Duodenal Ulcer, Erosive Esophagitis, Gastric Ulcer, Gastroesophageal Reflux Disease, Zollinger-Ellison Syndrome, Hyperphosphatemia
PubMed

PubMed

TitleDatePubMed
Exchange of sodium by magnesium in aluminum hydroxycarbonate gel.
1984 Jul
Automation of dihydroxyaluminum sodium carbonate analysis in antacid tablets by energy dispersive X-ray fluorescence.
1990 May-Jun
Effect of pepsin on the kinetics of HCl neutralization by dihydroxyaluminum sodium carbonate, hydrotalcite and dihydroxyaluminum aminoacetate.
1991
Patents

Sample Use Guides

Usual Adult Dose for Dyspepsia: 500 to 600 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Duodenal Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Erosive Esophagitis: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Gastric Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Gastroesophageal Reflux Disease: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Zollinger-Ellison Syndrome: 500 to 3600 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Hyperphosphatemia: 500 to 1000 mg orally 4 times a day, with meals and at bedtime. The dosage should be titrated to the serum phosphate level.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
CARBONATE ION
Common Name English
Carbonate [WHO-DD]
Common Name English
CARBONATE
WHO-DD  
Systematic Name English
Classification Tree Code System Code
LOINC 2033-9
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DSLD 747 (Number of products:2)
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LOINC 2034-7
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NCI_THESAURUS C597
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CFR 21 CFR 331.11
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LOINC 14641-5
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LOINC 2035-4
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Code System Code Type Description
SMS_ID
100000125923
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WIKIPEDIA
CARBONATE
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MESH
D002254
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FDA UNII
7UJQ5OPE7D
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CAS
3812-32-6
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RXCUI
1544139
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PRIMARY RxNorm
CHEBI
41609
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DRUG BANK
DB14531
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NCI_THESAURUS
C82598
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EVMPD
SUB32966
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EPA CompTox
DTXSID70872973
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PUBCHEM
19660
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DAILYMED
7UJQ5OPE7D
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