EGTA DISODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H20N2O10.2Na.2H
Molecular Weight	424.3114
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H+].[H+].[Na+].[Na+].[O-]C(=O)CN(CCOCCOCCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

InChIKey=PSNPATLUBMVVTM-UHFFFAOYSA-L

InChI=1S/C14H24N2O10.2Na/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24;;/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24);;/q;2*+1/p-2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29075867

Egtazic acid or EGTA is widely used for biological research as a chelating agent relatively more specific for calcium ions.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
calcium ion 2 Target ID: calcium ion Sources: https://www.ncbi.nlm.nih.gov/pubmed/12669884	Chelating Agent 139

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells.	2001-06-01	11278360
Hormone-specific combinations of isoforms of adenylyl cyclase and phosphodiesterase in the rat liver.	2001-05-05	11257314
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway.	2001-04-27	11278341
Purification and characterization of a plasmin-like protease from Tenodera sinensis (Chinese mantis).	2001-04-27	11267896
Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells.	2001-04-01	11274974
Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis.	2001-04-01	11254687
Site-specific calcium-dependent proteolysis of neuronal protein GAP-43.	2001-04	11274743
Heterogeneous increases of cytoplasmic calcium: distinct effects on down-regulation of cell surface sodium channels and sodium channel subunit mRNA levels.	2001-04	11264239
The effects of exogenous calcium buffers on the systolic calcium transient in rat ventricular myocytes.	2001-04	11259304
E-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating Akt kinase activity.	2001-04	11259266
Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.	2001-04	11247938
Changes in cardiac contractile function and myocardial.	2001-04	11247809
Angiotensin II stimulates cardiac L-type Ca(2+) current by a Ca(2+)- and protein kinase C-dependent mechanism.	2001-04	11247763
Calcium buffering and protection from excitotoxic cell death by exogenous calbindin-D28k in HEK 293 cells.	2001-04	11243935
Calcium requirement for efficient phagocytosis by Dictyostelium discoideum.	2001-04	11243931
Cytosolic Ca(2+) signal is involved in regulating UV-induced apoptosis in hela cells.	2001-03-23	11263975
EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo.	2001-03-20	11268280
Calcium-dependent structural changes in scallop heavy meromyosin.	2001-03-16	11243809
Role of Fas and granule exocytosis pathways in tumor-infiltrating T lymphocyte-induced apoptosis of autologous human lung-carcinoma cells.	2001-03-15	11275978
Monodansylcadaverine inhibits cytotoxicity of Vibrio parahaemolyticus thermostable direct hemolysin on cultured rat embryonic fibroblast cells.	2001-03-15	11267763
Transmitter release modulation by intracellular Ca2+ buffers in facilitating and depressing nerve terminals of pyramidal cells in layer 2/3 of the rat neocortex indicates a target cell-specific difference in presynaptic calcium dynamics.	2001-03-15	11251060
Increased Ca2+ buffering enhances Ca2+-dependent process.	2001-03-15	11251041
Differential regulation of transmitter release by presynaptic and glial Ca2+ internal stores at the neuromuscular synapse.	2001-03-15	11245676
A23187 causes release of inositol phosphates from cultured rat Kupffer cells.	2001-03-09	11245846
Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation.	2001-03-02	11270625
Evidence of calcium influx across the plasma membrane depends upon the initial rise of cytosolic calcium with activation of IP(3) in rat enterocytes by heat-stable enterotoxin of Vibrio cholerae non-O1.	2001-03-01	11257546
Contribution of postsynaptic Ca2+ to the induction of post-tetanic potentiation in the neural circuit for siphon withdrawal in Aplysia.	2001-03-01	11222663
Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration.	2001-03	11273652
Calcium-magnesium interactions in pancreatic acinar cells.	2001-03	11259384
The unusual gradient elution for reversed phase HPLC of a strong chelator as an active drug substance.	2001-03	11248490
Intraplatelet calcium levels in patients with acute renal failure before and after the administration of loop diuretics.	2001-03	11239030
The role of calcium signaling in early axonal and dendritic morphogenesis of rat cerebral cortex neurons under non-stimulated growth conditions.	2001-02-28	11248350
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.	2001-02-28	11223176
Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo.	2001-02-03	11275422
Characterization of adenylyl cyclases in cultured human granulosa cells.	2001-02	11226046
Characterization of oxyntic glands isolated from the rat gastric mucosa.	2001-02	11223396
Caffeine stores and dopamine differentially require Ca(2+) channels in goldfish somatotropes.	2001-02	11208580
Role of elementary Ca(2+) puffs in generating repetitive Ca(2+) oscillations.	2001-01-15	11226156
Characterization of the ryanodine receptor-Ca2+ release channel from the thoracic tissues of the lepidopteran insect Heliothis virescens.	2001-01-15	11220363
Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin.	2001-01	11265644
Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase.	2001-01	11235017
[Transition metals and nitric oxide production in human endothelial cells].	2001-01	11212498
CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets.	2001-01	11204565
Effects of Mannheimia haemolytica leukotoxin on apoptosis and oncosis of bovine neutrophils.	2001-01	11197552
Calcium-induced conformational changes in Leishmania infantum kinetoplastid membrane protein-11.	2001-01	11191218
Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth.	2001	11250759
Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells.	2001	11237416
Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells.	2001	11231888
Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.	2001	11231886
Intercellular calcium signaling and flash photolysis of caged compounds. A sensitive method to evaluate gap junctional coupling.	2001	11218662

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

EGTA DISODIUM

Common Name

English

6,9-DIOXA-3,12-DIAZATETRADECANEDIOIC ACID, 3,12-BIS(CARBOXYMETHYL)-, DISODIUM SALT

Preferred Name

English

6,9-DIOXA-3,12-DIAZATETRADECANEDIOIC ACID, 3,12-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:2)

Common Name

English

ACETIC ACID, (ETHYLENEBIS(OXYETHYLENENITRILO))TETRA-, DISODIUM SALT

Common Name

English

EGTA DISODIUM SALT [MI]

Common Name

English

Code System Code Type Description

CAS

26082-78-0